Abstract
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor κB pathway controls and coordinates B-cell division and survival following TLR4 engagement.
Original language | English |
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Pages (from-to) | 471-475 |
Number of pages | 5 |
Journal | Immunology and Cell Biology |
Volume | 85 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Aug 2007 |
Externally published | Yes |
Keywords
- Apoptosis
- Cell cycle
- ERK
- NF-κB
- TLR4 signaling