Regulating B-cell activation and survival in response to TLR signals

Steve Gerondakis, Raelene J. Grumont, Ashish Banerjee

Research output: Contribution to journalReview ArticleResearchpeer-review

63 Citations (Scopus)

Abstract

Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor κB pathway controls and coordinates B-cell division and survival following TLR4 engagement.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalImmunology and Cell Biology
Volume85
Issue number6
DOIs
Publication statusPublished - 1 Aug 2007
Externally publishedYes

Keywords

  • Apoptosis
  • Cell cycle
  • ERK
  • NF-κB
  • TLR4 signaling

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