TY - JOUR
T1 - Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis
AU - Younes, Laurent
AU - Ratnanather, J. Tilak
AU - Brown, Timothy
AU - Aylward, Elizabeth
AU - Nopoulos, Peg
AU - Johnson, Hans
AU - Magnotta, Vincent A.
AU - Paulsen, Jane S.
AU - Margolis, Russell L.
AU - Albin, Roger L.
AU - Miller, Michael I.
AU - Ross, Christopher A.
AU - PREDICT-D Investigators and Coordinators of the Huntington Study Group
AU - Chua, Phyllis
AU - Georgiou-Karistianis, Nellie
PY - 2014/3
Y1 - 2014/3
N2 - Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
AB - Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
KW - Diffeomorphic mapping
KW - Pallidus atrophy
KW - Striatal atrophy
KW - Surface registration
KW - Surface-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84893816723&partnerID=8YFLogxK
U2 - 10.1002/hbm.22214
DO - 10.1002/hbm.22214
M3 - Article
C2 - 23281100
AN - SCOPUS:84893816723
SN - 1065-9471
VL - 35
SP - 792
EP - 809
JO - Human Brain Mapping
JF - Human Brain Mapping
IS - 3
ER -