Regional systemic ANP differences in fetal lambs

Role of coronary sinus outflow distribution

J. J. Smolich, R. L. Woods

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Although it is known that the atrial natriuretic peptide (ANP) level in right ventricular (RV) blood supplying the caudal part of the fetus is greater than in left ventricular blood perfusing the cephalic part of the fetus, the extent to which any preferential passage of coronary sinus blood into the right ventricle contributes to regional differences between ANP levels in fetal cephalic and caudal arteries is unknown. To address this question, experiments were performed in eight late-gestation fetal lambs, 3- 7 days after catheters were inserted into the left atrium, major arteries and veins, and coronary sinus (via the left hemiazygous vein). The plasma ANP level in the abdominal aorta (171 ± 33 pg/ml) was higher than in the carotid artery (103 ± 15 pg/ml; P < 0.05), and both were lower than in the coronary sinus (736 ± 89 pg/ml; P < 0.005). The coronary sinus outflow, measured with radioactive microspheres injected into the hemiazygous vein, was preferentially distributed to the right ventricle (94.7 ± 1.3%) and thence to the abdominal aorta (89.5 ± 1.6%). This streaming of the coronary sinus outflow contributed 13.3 ± 0.9 and 1.4 ± 0.4 pg/ml to ANP levels in the abdominal aorta and carotid artery, respectively, and thereby accounted for 11.9 ± 0.9 pg/ml of the abdominal aorta-carotid artery ANP difference of 68 ± 25 pg/ml. We conclude that, in fetal sheep, 1) the coronary sinus outflow contains high plasma levels of ANP; 2) because of preferential passage of the coronary sinus outflow into the right ventricle, most of the ANP present in coronary sinus blood enters the abdominal aorta; 3) preferential passage of coronary sinus-derived ANP into the abdominal aorta accounts for < 20% of the difference between ANP levels in cephalic and caudal arteries; 4) most of the cephalo-caudal arterial ANP difference is probably related to a greater secretion of ANP directly into the right heart chambers.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume269
Issue number2 38-2
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • atrial natriuretic peptide
  • fetus
  • radioactive microspheres

Cite this

@article{2946182e92e3435eb7384cd67f2353ce,
title = "Regional systemic ANP differences in fetal lambs: Role of coronary sinus outflow distribution",
abstract = "Although it is known that the atrial natriuretic peptide (ANP) level in right ventricular (RV) blood supplying the caudal part of the fetus is greater than in left ventricular blood perfusing the cephalic part of the fetus, the extent to which any preferential passage of coronary sinus blood into the right ventricle contributes to regional differences between ANP levels in fetal cephalic and caudal arteries is unknown. To address this question, experiments were performed in eight late-gestation fetal lambs, 3- 7 days after catheters were inserted into the left atrium, major arteries and veins, and coronary sinus (via the left hemiazygous vein). The plasma ANP level in the abdominal aorta (171 ± 33 pg/ml) was higher than in the carotid artery (103 ± 15 pg/ml; P < 0.05), and both were lower than in the coronary sinus (736 ± 89 pg/ml; P < 0.005). The coronary sinus outflow, measured with radioactive microspheres injected into the hemiazygous vein, was preferentially distributed to the right ventricle (94.7 ± 1.3{\%}) and thence to the abdominal aorta (89.5 ± 1.6{\%}). This streaming of the coronary sinus outflow contributed 13.3 ± 0.9 and 1.4 ± 0.4 pg/ml to ANP levels in the abdominal aorta and carotid artery, respectively, and thereby accounted for 11.9 ± 0.9 pg/ml of the abdominal aorta-carotid artery ANP difference of 68 ± 25 pg/ml. We conclude that, in fetal sheep, 1) the coronary sinus outflow contains high plasma levels of ANP; 2) because of preferential passage of the coronary sinus outflow into the right ventricle, most of the ANP present in coronary sinus blood enters the abdominal aorta; 3) preferential passage of coronary sinus-derived ANP into the abdominal aorta accounts for < 20{\%} of the difference between ANP levels in cephalic and caudal arteries; 4) most of the cephalo-caudal arterial ANP difference is probably related to a greater secretion of ANP directly into the right heart chambers.",
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Regional systemic ANP differences in fetal lambs : Role of coronary sinus outflow distribution. / Smolich, J. J.; Woods, R. L.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 269, No. 2 38-2, 1995.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Woods, R. L.

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AB - Although it is known that the atrial natriuretic peptide (ANP) level in right ventricular (RV) blood supplying the caudal part of the fetus is greater than in left ventricular blood perfusing the cephalic part of the fetus, the extent to which any preferential passage of coronary sinus blood into the right ventricle contributes to regional differences between ANP levels in fetal cephalic and caudal arteries is unknown. To address this question, experiments were performed in eight late-gestation fetal lambs, 3- 7 days after catheters were inserted into the left atrium, major arteries and veins, and coronary sinus (via the left hemiazygous vein). The plasma ANP level in the abdominal aorta (171 ± 33 pg/ml) was higher than in the carotid artery (103 ± 15 pg/ml; P < 0.05), and both were lower than in the coronary sinus (736 ± 89 pg/ml; P < 0.005). The coronary sinus outflow, measured with radioactive microspheres injected into the hemiazygous vein, was preferentially distributed to the right ventricle (94.7 ± 1.3%) and thence to the abdominal aorta (89.5 ± 1.6%). This streaming of the coronary sinus outflow contributed 13.3 ± 0.9 and 1.4 ± 0.4 pg/ml to ANP levels in the abdominal aorta and carotid artery, respectively, and thereby accounted for 11.9 ± 0.9 pg/ml of the abdominal aorta-carotid artery ANP difference of 68 ± 25 pg/ml. We conclude that, in fetal sheep, 1) the coronary sinus outflow contains high plasma levels of ANP; 2) because of preferential passage of the coronary sinus outflow into the right ventricle, most of the ANP present in coronary sinus blood enters the abdominal aorta; 3) preferential passage of coronary sinus-derived ANP into the abdominal aorta accounts for < 20% of the difference between ANP levels in cephalic and caudal arteries; 4) most of the cephalo-caudal arterial ANP difference is probably related to a greater secretion of ANP directly into the right heart chambers.

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