TY - JOUR
T1 - Regional Slow Waves and Spindles in Human Sleep
AU - Nir, Yuval
AU - Staba, Richard J.
AU - Andrillon, Thomas
AU - Vyazovskiy, Vladyslav V.
AU - Cirelli, Chiara
AU - Fried, Itzhak
AU - Tononi, Giulio
PY - 2011/4/14
Y1 - 2011/4/14
N2 - The most prominent EEG events in sleep are slow waves, reflecting a slow (<1 Hz) oscillation between up and down states in cortical neurons. It is unknown whether slow oscillations are synchronous across the majority or the minority of brain regions-are they a global or local phenomenon? To examine this, we recorded simultaneously scalp EEG, intracerebral EEG, and unit firing in multiple brain regions of neurosurgical patients. We find that most sleep slow waves and the underlying active and inactive neuronal states occur locally. Thus, especially in late sleep, some regions can be active while others are silent. We also find that slow waves can propagate, usually from medial prefrontal cortex to the medial temporal lobe and hippocampus. Sleep spindles, the other hallmark of NREM sleep EEG, are likewise predominantly local. Thus, intracerebral communication during sleep is constrained because slow and spindle oscillations often occur out-of-phase in different brain regions.
AB - The most prominent EEG events in sleep are slow waves, reflecting a slow (<1 Hz) oscillation between up and down states in cortical neurons. It is unknown whether slow oscillations are synchronous across the majority or the minority of brain regions-are they a global or local phenomenon? To examine this, we recorded simultaneously scalp EEG, intracerebral EEG, and unit firing in multiple brain regions of neurosurgical patients. We find that most sleep slow waves and the underlying active and inactive neuronal states occur locally. Thus, especially in late sleep, some regions can be active while others are silent. We also find that slow waves can propagate, usually from medial prefrontal cortex to the medial temporal lobe and hippocampus. Sleep spindles, the other hallmark of NREM sleep EEG, are likewise predominantly local. Thus, intracerebral communication during sleep is constrained because slow and spindle oscillations often occur out-of-phase in different brain regions.
UR - http://www.scopus.com/inward/record.url?scp=79953778727&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2011.02.043
DO - 10.1016/j.neuron.2011.02.043
M3 - Article
C2 - 21482364
AN - SCOPUS:79953778727
SN - 0896-6273
VL - 70
SP - 153
EP - 169
JO - Neuron
JF - Neuron
IS - 1
ER -