Regional localization of the TIMP gene on the human X chromosome - Extension of a conserved synteny and linkage group on proximal Xp

H. F. Willard, S. J. Durfy, M. M. Mahtani, H. Dorkins, K. E. Davies, B. R.G. Williams

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The gene encoding a tissue inhibitor of metalloproteinases, TIMP, has previously been shown to be X-linked in both the human and mouse genomes. We have used a series of somatic cell hybrids segregating translocation and deletion X chromosomes to map the TIMP gene on the human X chromosome. In combination with previous data, the gene can be assigned to Xp11.23→Xp11.4. Genetic linkage analyses demonstrate that TIMP is linked to the more distal ornithine transcarbamylase (OTC) locus at a distance of about 22 centimorgans. The data are consistent with the conclusion that TIMP maps to a conserved synteny and linkage group on the proximal short arm of the human X chromosome and on the pericentric region of the mouse X chromosome, including loci for synapsin-1, a member of the raf oncogene family, OTC, and TIMP.

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalHuman Genetics
Issue number3
Publication statusPublished - 1 Feb 1989
Externally publishedYes

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