Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?

Chen Chen, Jiansong Zhou, Chunhong Liu, Katrina Witt, Yingdong Zhang, Bin Jing, Chun Li, Xiaoping Wang, Lianjiang Li

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4 Citations (Scopus)


The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.
Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
Publication statusPublished - 2015
Externally publishedYes

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