TY - JOUR
T1 - Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders
T2 - A biomarker of brain immaturity?
AU - Chen, Chen
AU - Zhou, Jiansong
AU - Liu, Chunhong
AU - Witt, Katrina
AU - Zhang, Yingdong
AU - Jing, Bin
AU - Li, Chun
AU - Wang, Xiaoping
AU - Li, Lianjiang
PY - 2015
Y1 - 2015
N2 - The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.
AB - The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.
UR - http://neuro.psychiatryonline.org/doi/abs/10.1176/appi.neuropsych.13030044
U2 - 10.1176/appi.neuropsych.13030044
DO - 10.1176/appi.neuropsych.13030044
M3 - Article
SN - 0895-0172
VL - 27
SP - 27
EP - 32
JO - The Journal of Neuropsychiatry and Clinical Neurosciences
JF - The Journal of Neuropsychiatry and Clinical Neurosciences
IS - 1
ER -
