Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?

Chen Chen, Jiansong Zhou, Chunhong Liu, Katrina Witt, Yingdong Zhang, Bin Jing, Chun Li, Xiaoping Wang, Lianjiang Li

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.
Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume27
Issue number1
DOIs
Publication statusPublished - 2015
Externally publishedYes

Cite this

Chen, Chen ; Zhou, Jiansong ; Liu, Chunhong ; Witt, Katrina ; Zhang, Yingdong ; Jing, Bin ; Li, Chun ; Wang, Xiaoping ; Li, Lianjiang. / Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders : A biomarker of brain immaturity?. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2015 ; Vol. 27, No. 1. pp. 27-32.
@article{0c9a30c95d9e4aa8b8514db57d7a70e2,
title = "Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?",
abstract = "The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.",
author = "Chen Chen and Jiansong Zhou and Chunhong Liu and Katrina Witt and Yingdong Zhang and Bin Jing and Chun Li and Xiaoping Wang and Lianjiang Li",
year = "2015",
doi = "10.1176/appi.neuropsych.13030044",
language = "English",
volume = "27",
pages = "27--32",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing",
number = "1",

}

Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders : A biomarker of brain immaturity? / Chen, Chen; Zhou, Jiansong; Liu, Chunhong; Witt, Katrina; Zhang, Yingdong; Jing, Bin; Li, Chun; Wang, Xiaoping; Li, Lianjiang.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 27, No. 1, 2015, p. 27-32.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders

T2 - A biomarker of brain immaturity?

AU - Chen, Chen

AU - Zhou, Jiansong

AU - Liu, Chunhong

AU - Witt, Katrina

AU - Zhang, Yingdong

AU - Jing, Bin

AU - Li, Chun

AU - Wang, Xiaoping

AU - Li, Lianjiang

PY - 2015

Y1 - 2015

N2 - The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.

AB - The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.

UR - http://neuro.psychiatryonline.org/doi/abs/10.1176/appi.neuropsych.13030044

U2 - 10.1176/appi.neuropsych.13030044

DO - 10.1176/appi.neuropsych.13030044

M3 - Article

VL - 27

SP - 27

EP - 32

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 1

ER -