Regio- and stereoselective iodoacyloxylations of alkynes

Daniel Priebbenow, Robert W Gable, Jonathan Bayldon Baell

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A new method for the regioselective and stereoselective iodoacyloxylation of alkynes has been developed. This protocol utilizes a combination of an iodobenzene dicarboxylate and iodine to functionalize a series of activated and unactivated alkynes in an entirely selective and predictable fashion. The resultant iodo-enol esters were subsequently coupled with boronic acids to afford tetrasubstituted alkene derivatives, which could be further converted to the corresponding 1,1-disubstituted acetophenone.
Original languageEnglish
Pages (from-to)4412 - 4418
Number of pages7
JournalJournal of Organic Chemistry
Volume80
Issue number9
DOIs
Publication statusPublished - 2015

Cite this

Priebbenow, Daniel ; Gable, Robert W ; Baell, Jonathan Bayldon. / Regio- and stereoselective iodoacyloxylations of alkynes. In: Journal of Organic Chemistry. 2015 ; Vol. 80, No. 9. pp. 4412 - 4418.
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Regio- and stereoselective iodoacyloxylations of alkynes. / Priebbenow, Daniel; Gable, Robert W; Baell, Jonathan Bayldon.

In: Journal of Organic Chemistry, Vol. 80, No. 9, 2015, p. 4412 - 4418.

Research output: Contribution to journalArticleResearchpeer-review

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