Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of gata3

Caghan Kizil, Nikos Kyritsis, Stefanie Dudczig, Volker Kroehne, Dorian Freudenreich, Jan V Kaslin, Michael Brand

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)


The adult zebrafish brain, unlike mammalian counterparts, can regenerate after injury owing to the neurogenic capacity of stem cells with radial glial character. We hypothesized that injury-induced regenerative programs might be turned on after injury in zebrafish brain and enable regenerative neurogenesis. Here we identify one such gene-the transcription factor gata3-which is expressed only after injury in different zebrafish organs. Gata3 is required for reactive proliferation of radial glia cells, subsequent regenerative neurogenesis, and migration of the newborn neurons. We found that these regeneration-specific roles of Gata3 are dependent on the injury because Gata3 overexpression in the unlesioned adult zebrafish brain is not sufficient to induce neurogenesis. Thus, gata3 acts as a specific injury-induced proregenerative factor that is essential for the regenerative capacity in vertebrates.
Original languageEnglish
Pages (from-to)1230 - 1237
Number of pages8
JournalDevelopmental Cell
Issue number6
Publication statusPublished - 2012

Cite this