Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases

Yongping Bao; Per Jemth; Bengt Mannervik; Gary Williamson

doi:10.1016/S0014-5793(97)00591-7

Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases

Yongping Bao, Per Jemth, Bengt Mannervik, Gary Williamson

Research output: Contribution to journal › Article › Research › peer-review

50 Citations (Scopus)

Abstract

Thymine hydroperoxide (5-hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium-dependent human phospholipid hydroperoxide glutathione peroxidase (Se-PHGPx) exhibits about four orders of magnitude higher activity on thymine hydroperoxide than that of other human enzymes such as selenium-dependent glutathione peroxidase and various representatives of glutathione transferases. The results indicate that Se-PHGPx may be an important enzyme in repairing oxidatively damaged DNA.

Original language	English
Pages (from-to)	210-212
Number of pages	3
Journal	FEBS Letters
Volume	410
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(97)00591-7
Publication status	Published - 30 Jun 1997
Externally published	Yes

Keywords

Glutathione peroxidase
Glutathione transferase
Phospholipid hydroperoxide glutathione peroxidase
Selenium
Thymine hydroperoxide

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10.1016/S0014-5793(97)00591-7

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title = "Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases",

abstract = "Thymine hydroperoxide (5-hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium-dependent human phospholipid hydroperoxide glutathione peroxidase (Se-PHGPx) exhibits about four orders of magnitude higher activity on thymine hydroperoxide than that of other human enzymes such as selenium-dependent glutathione peroxidase and various representatives of glutathione transferases. The results indicate that Se-PHGPx may be an important enzyme in repairing oxidatively damaged DNA.",

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T1 - Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases

AU - Bao, Yongping

AU - Jemth, Per

AU - Mannervik, Bengt

AU - Williamson, Gary

PY - 1997/6/30

Y1 - 1997/6/30

N2 - Thymine hydroperoxide (5-hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium-dependent human phospholipid hydroperoxide glutathione peroxidase (Se-PHGPx) exhibits about four orders of magnitude higher activity on thymine hydroperoxide than that of other human enzymes such as selenium-dependent glutathione peroxidase and various representatives of glutathione transferases. The results indicate that Se-PHGPx may be an important enzyme in repairing oxidatively damaged DNA.

AB - Thymine hydroperoxide (5-hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium-dependent human phospholipid hydroperoxide glutathione peroxidase (Se-PHGPx) exhibits about four orders of magnitude higher activity on thymine hydroperoxide than that of other human enzymes such as selenium-dependent glutathione peroxidase and various representatives of glutathione transferases. The results indicate that Se-PHGPx may be an important enzyme in repairing oxidatively damaged DNA.

KW - Glutathione peroxidase

KW - Glutathione transferase

KW - Phospholipid hydroperoxide glutathione peroxidase

KW - Selenium

KW - Thymine hydroperoxide

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DO - 10.1016/S0014-5793(97)00591-7

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AN - SCOPUS:0030786577

SN - 0014-5793

VL - 410

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JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -

Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases

Abstract

Keywords

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