Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases

Yongping Bao, Per Jemth, Bengt Mannervik, Gary Williamson

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Abstract

Thymine hydroperoxide (5-hydroperoxymethyluracil), a model compound representing products of oxidative damage to DNA, is a substrate for glutathione peroxidase and some isoforms of glutathione transferase. In this paper, we show that selenium-dependent human phospholipid hydroperoxide glutathione peroxidase (Se-PHGPx) exhibits about four orders of magnitude higher activity on thymine hydroperoxide than that of other human enzymes such as selenium-dependent glutathione peroxidase and various representatives of glutathione transferases. The results indicate that Se-PHGPx may be an important enzyme in repairing oxidatively damaged DNA.

Original languageEnglish
Pages (from-to)210-212
Number of pages3
JournalFEBS Letters
Volume410
Issue number2-3
DOIs
Publication statusPublished - 30 Jun 1997
Externally publishedYes

Keywords

  • Glutathione peroxidase
  • Glutathione transferase
  • Phospholipid hydroperoxide glutathione peroxidase
  • Selenium
  • Thymine hydroperoxide

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