Abstract
Cerebrovascular injury is one of the major detrimental consequences of preterm birth. Recent studies have focused their attention on factors that contribute to the development of brain lesions immediately after birth. Among those factors, hypothermia and lower cerebral oxygen saturation during delivery room resuscitation and high tidal volumes delivered during respiratory support are associated with increased risk of severe neurologic injury. In preterm infants, knowledge about causes and prevention of brain injury must be applied before and at birth. Preventive and therapeutic approaches, including correct timing of cord clamping, monitoring of physiological changes during delivery room resuscitation using pulse oximetry, respiratory function monitoring, near infrared spectroscopy, and alpha EEG, may minimize brain injury, Furthermore, postnatal administration of caffeine or other potential novel treatments (e.g., proangiogenic therapies, antioxidants, hormones, or stem cells) might improve long-term neurodevelopmental outcomes in preterm infants.
| Original language | English |
|---|---|
| Article number | 290 |
| Number of pages | 7 |
| Journal | Frontiers in Pediatrics |
| Volume | 6 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Keywords
- Brain injury
- Infants
- Intraventricular hemorrhage
- Neonatal resuscitation
- Newborn
- Very low birth weight infants
Cite this
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Reducing brain injury of preterm infants in the delivery room. / Viaroli, Francesca; Cheung, Po Yin; O'Reilly, Megan; Polglase, Graeme R.; Pichler, Gerhard; Schmölzer, Georg M.
In: Frontiers in Pediatrics, Vol. 6, 290, 01.01.2018.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Reducing brain injury of preterm infants in the delivery room
AU - Viaroli, Francesca
AU - Cheung, Po Yin
AU - O'Reilly, Megan
AU - Polglase, Graeme R.
AU - Pichler, Gerhard
AU - Schmölzer, Georg M.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Cerebrovascular injury is one of the major detrimental consequences of preterm birth. Recent studies have focused their attention on factors that contribute to the development of brain lesions immediately after birth. Among those factors, hypothermia and lower cerebral oxygen saturation during delivery room resuscitation and high tidal volumes delivered during respiratory support are associated with increased risk of severe neurologic injury. In preterm infants, knowledge about causes and prevention of brain injury must be applied before and at birth. Preventive and therapeutic approaches, including correct timing of cord clamping, monitoring of physiological changes during delivery room resuscitation using pulse oximetry, respiratory function monitoring, near infrared spectroscopy, and alpha EEG, may minimize brain injury, Furthermore, postnatal administration of caffeine or other potential novel treatments (e.g., proangiogenic therapies, antioxidants, hormones, or stem cells) might improve long-term neurodevelopmental outcomes in preterm infants.
AB - Cerebrovascular injury is one of the major detrimental consequences of preterm birth. Recent studies have focused their attention on factors that contribute to the development of brain lesions immediately after birth. Among those factors, hypothermia and lower cerebral oxygen saturation during delivery room resuscitation and high tidal volumes delivered during respiratory support are associated with increased risk of severe neurologic injury. In preterm infants, knowledge about causes and prevention of brain injury must be applied before and at birth. Preventive and therapeutic approaches, including correct timing of cord clamping, monitoring of physiological changes during delivery room resuscitation using pulse oximetry, respiratory function monitoring, near infrared spectroscopy, and alpha EEG, may minimize brain injury, Furthermore, postnatal administration of caffeine or other potential novel treatments (e.g., proangiogenic therapies, antioxidants, hormones, or stem cells) might improve long-term neurodevelopmental outcomes in preterm infants.
KW - Brain injury
KW - Infants
KW - Intraventricular hemorrhage
KW - Neonatal resuscitation
KW - Newborn
KW - Very low birth weight infants
UR - http://www.scopus.com/inward/record.url?scp=85056396957&partnerID=8YFLogxK
U2 - 10.3389/fped.2018.00290
DO - 10.3389/fped.2018.00290
M3 - Review Article
AN - SCOPUS:85056396957
VL - 6
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
SN - 2296-2360
M1 - 290
ER -