Reduced V1 Vasopressin binding in the rat nucleus solitarii after Nodose Ganglionectomy

P. A. Phillips, R. E. Widdop, S. ‐Y Chai, J. Kelly, V. Mooser, D. Trinder, C. I. Johnston

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

1. Anaesthetized male Sprague‐Dawley rats underwent unilateral nodose ganglionectomy or sham operation. 2. One week later hindbrain V1 vasopressin binding site density was assessed by in vitro autoradiography with the selective V1 antagonist radiolgand [125I] [d(CH2)5, Sar7]AVP. 3. Specific binding was observed in the nodose ganglion, nucleus tractus solitarius (NTS), area postrema, and inferior olive. Only binding in the medial subnucleus of the NTS was reduced by ipsilateral nodose ganglionectomy. 4. These findings are consistent with V1 vasopressin receptors occurring pre‐synaptically on vagal primary viscerosensory afferent fibres. 5. Such receptors may be involved in the effect of AVP on blood pressure and/or the baroreflex.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Keywords

  • baroreceptor
  • binding site density
  • blood pressure
  • nodose ganglionectomy
  • nucleus tractus solitarii
  • V vasopressin receptor
  • vasopressin
  • [I][d(CH), Sar]AVP

Cite this