TY - JOUR
T1 - Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection
AU - Peleg, Anton Yariv
AU - Monga, Divya
AU - Pillai, Satish
AU - Mylonakis, Eleftherios
AU - Moellering Jr, Robert C
AU - Eliopoulos, George M
PY - 2009
Y1 - 2009
N2 - In the present study, we demonstrated the utility of the nonmammalian model system Galleria mellonella for studying the pathogenesis of Staphylococcus aureus infection. By use of clinical and laboratory strains that had been exposed to vancomycin, we showed that both agr functional status and vancomycin minimum inhibitory concentration are determinants associated with the virulence of S. aureus in G. mellonella. These results show that G. mellonella can be effectively used to facilitate the in vivo study of S. aureus virulence and, more specifically, the relationship between antibiotic drug resistance and the pathogenesis of infection.
AB - In the present study, we demonstrated the utility of the nonmammalian model system Galleria mellonella for studying the pathogenesis of Staphylococcus aureus infection. By use of clinical and laboratory strains that had been exposed to vancomycin, we showed that both agr functional status and vancomycin minimum inhibitory concentration are determinants associated with the virulence of S. aureus in G. mellonella. These results show that G. mellonella can be effectively used to facilitate the in vivo study of S. aureus virulence and, more specifically, the relationship between antibiotic drug resistance and the pathogenesis of infection.
UR - http://www.journals.uchicago.edu/doi/pdf/10.1086/596511
U2 - 10.1086/596511
DO - 10.1086/596511
M3 - Article
SN - 0022-1899
VL - 199
SP - 532
EP - 536
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 4
ER -