TY - JOUR
T1 - Reduced prefrontal short-latency afferent inhibition in older adults and its relation to executive function
T2 - A TMS-EEG study
AU - Noda, Yoshihiro
AU - Zomorrodi-Moghaddam, Reza
AU - Backhouse, Felicity
AU - Cash, Robin F.H.
AU - Barr, Mera S
AU - Rajji, Tarek K
AU - Chen, Robert
AU - Daskalakis, Zafiris Jeff
AU - Blumberger, Daniel M
PY - 2017/5/2
Y1 - 2017/5/2
N2 - Combining transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for the assessment of various neurophysiological processes in the human cortex. One of these paradigms, short-latency afferent inhibition (SAI), is thought to be a sensitive measure of cholinergic activity. In a previous study, we demonstrated the temporal pattern of this paradigm from both the motor (M1) and dorsolateral prefrontal cortex (DLPFC) using simultaneous TMS-EEG recording. The SAI paradigm led to marked modulations at N100. In this study, we aimed to investigate the age-related effects on TMS-evoked potentials (TEPs) with the SAI from M1 and the DLPFC in younger (18-59 years old) and older (≥60 years old) participants. Older participants showed significantly lower N100 modulation in M1-SAI as well as DLPFC-SAI compared to the younger participants. Furthermore, the modulation of N100 by DLPFC-SAI in the older participants correlated with executive function as measured with the Trail making test. This paradigm has the potential to non-invasively identify cholinergic changes in cortical regions related to cognition in older participants.
AB - Combining transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for the assessment of various neurophysiological processes in the human cortex. One of these paradigms, short-latency afferent inhibition (SAI), is thought to be a sensitive measure of cholinergic activity. In a previous study, we demonstrated the temporal pattern of this paradigm from both the motor (M1) and dorsolateral prefrontal cortex (DLPFC) using simultaneous TMS-EEG recording. The SAI paradigm led to marked modulations at N100. In this study, we aimed to investigate the age-related effects on TMS-evoked potentials (TEPs) with the SAI from M1 and the DLPFC in younger (18-59 years old) and older (≥60 years old) participants. Older participants showed significantly lower N100 modulation in M1-SAI as well as DLPFC-SAI compared to the younger participants. Furthermore, the modulation of N100 by DLPFC-SAI in the older participants correlated with executive function as measured with the Trail making test. This paradigm has the potential to non-invasively identify cholinergic changes in cortical regions related to cognition in older participants.
KW - Age-related changes
KW - Cognition
KW - Dorsolateral prefrontal cortex
KW - Short-latency afferent inhibition
KW - TMS-EEG
UR - http://www.scopus.com/inward/record.url?scp=85020037959&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2017.00119
DO - 10.3389/fnagi.2017.00119
M3 - Article
AN - SCOPUS:85020037959
SN - 1663-4365
VL - 9
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
IS - MAY
M1 - 119
ER -