Abstract
Results: Here we provide evidence that Polycomb Repressive Complex 2 (PRC2) regulates paternal inheritance. Reduced PRC2 function in mice resulted in male sub-fertility and altered epigenetic and transcriptional control of retrotransposed elements in foetal male germ cells. Males with reduced PRC2 function produced offspring that over-expressed retrotransposed pseudogenes and had altered preimplantation embryo cleavage rates and cell cycle control.
Conclusion: This study reveals a novel role for the histone-modifying complex, PRC2, in paternal intergenerational transmission of epigenetic effects on offspring, with important implications for understanding disease inheritance.
| Original language | English |
|---|---|
| Article number | 104 |
| Number of pages | 20 |
| Journal | BMC Biology |
| Volume | 16 |
| DOIs | |
| Publication status | Published - 20 Sep 2018 |
Cite this
}
Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance. / Stringer, Jessica; Forster, Samuel; Qu, Zhipeng; Prokopuk, Lexie Ann; O'Bryan, Moira Kathleen; Gardner, David K.; White, Stefan; Adelson, David Louis; Western, Patrick Stephen.
In: BMC Biology, Vol. 16, 104, 20.09.2018.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance
AU - Stringer, Jessica
AU - Forster, Samuel
AU - Qu, Zhipeng
AU - Prokopuk, Lexie Ann
AU - O'Bryan, Moira Kathleen
AU - Gardner, David K.
AU - White, Stefan
AU - Adelson, David Louis
AU - Western, Patrick Stephen
PY - 2018/9/20
Y1 - 2018/9/20
N2 - Background: Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to offspring are poorly understood.Results: Here we provide evidence that Polycomb Repressive Complex 2 (PRC2) regulates paternal inheritance. Reduced PRC2 function in mice resulted in male sub-fertility and altered epigenetic and transcriptional control of retrotransposed elements in foetal male germ cells. Males with reduced PRC2 function produced offspring that over-expressed retrotransposed pseudogenes and had altered preimplantation embryo cleavage rates and cell cycle control.Conclusion: This study reveals a novel role for the histone-modifying complex, PRC2, in paternal intergenerational transmission of epigenetic effects on offspring, with important implications for understanding disease inheritance.
AB - Background: Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to offspring are poorly understood.Results: Here we provide evidence that Polycomb Repressive Complex 2 (PRC2) regulates paternal inheritance. Reduced PRC2 function in mice resulted in male sub-fertility and altered epigenetic and transcriptional control of retrotransposed elements in foetal male germ cells. Males with reduced PRC2 function produced offspring that over-expressed retrotransposed pseudogenes and had altered preimplantation embryo cleavage rates and cell cycle control.Conclusion: This study reveals a novel role for the histone-modifying complex, PRC2, in paternal intergenerational transmission of epigenetic effects on offspring, with important implications for understanding disease inheritance.
U2 - 10.1186/s12915-018-0569-5
DO - 10.1186/s12915-018-0569-5
M3 - Article
VL - 16
JO - BMC Biology
JF - BMC Biology
SN - 1741-7007
M1 - 104
ER -