Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep

Reetu Ragni Singh, Katherine Maude Denton, John Frederick Bertram, Andrew John Jefferies, Karen Margaret Moritz

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Reduced nephron endowment is associated with development of renal and cardiovascular disease. We hypothesised this may be attributable to impaired sodium homeostasis by the remaining nephrons. This study investigated whether a nephron deficit, induced by fetal uninephrectomy at 100d gestation (term=150 days), resulted in 1) altered renal sodium handling both under basal conditions and in response to an acute 0.9 saline load, (50 ml/kg/30minutes); 2) hypertension; and 3) altered expression of renal channels/transporters in male sheep at 6 months of age. Uninephrectomised animals had significantly elevated arterial pressure (90.1+/-1.6 vs 77.8+/-2.9; P
Original languageEnglish
Pages (from-to)669 - 680
Number of pages12
JournalClinical Science
Issue number11/12
Publication statusPublished - 2010

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