Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep

Reetu Ragni Singh, Katherine Maude Denton, John Frederick Bertram, Andrew John Jefferies, Karen Margaret Moritz

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Abstract

Reduced nephron endowment is associated with development of renal and cardiovascular disease. We hypothesised this may be attributable to impaired sodium homeostasis by the remaining nephrons. This study investigated whether a nephron deficit, induced by fetal uninephrectomy at 100d gestation (term=150 days), resulted in 1) altered renal sodium handling both under basal conditions and in response to an acute 0.9 saline load, (50 ml/kg/30minutes); 2) hypertension; and 3) altered expression of renal channels/transporters in male sheep at 6 months of age. Uninephrectomised animals had significantly elevated arterial pressure (90.1+/-1.6 vs 77.8+/-2.9; P
Original languageEnglish
Pages (from-to)669 - 680
Number of pages12
JournalClinical Science
Volume118
Issue number11/12
DOIs
Publication statusPublished - 2010

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