Reduced L-arginine transport contributes to the pathogenesis of myocardial ischemia-reperfusion injury

Kylie Venardos, Amanda Zatta, Tanneale Marshall, Rebecca Ritchie, David Kaye

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

ABSTRACT Myocardial injury due to ischemia-reperfusion (I-R) damage remains a major clinical challenge. Its pathogenesis is complex including endothelial dysfunction and heightened oxidative stress although the key driving mechanism remains uncertain. In this study we tested the hypothesis that the I-R process induces a state of insufficient L-arginine availability for NO biosynthesis, and that this is pivotal in the development of myocardial I-R damage. In neonatal rat ventricular cardiomyocytes (NVCM), hypoxia-reoxygenation significantly decreased L-arginine uptake and NO production (42 2 and 71 4 , respectively, both P
Original languageEnglish
Pages (from-to)156 - 168
Number of pages13
JournalJournal of Cellular Biochemistry
Volume108
Issue number1
DOIs
Publication statusPublished - 2009

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