TY - JOUR
T1 - Reduced frequency of high cholesterol levels among patients with intracerebral haemorrhage
AU - Thrift, A.
AU - McNeil, J.
AU - Donnan, G.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - To determine whether a relationship exists between high cholesterol levels and intracerebral haemorrhage (ICH) a case-control study was undertaken on 331 consecutive cases of first-episode primary ICH, verified by computed tomography, and 331 age- and sex-matched community controls. Using conditional logistic regression the adjusted odds ratio (OR) of ICH among individuals reporting a high cholesterol level was 0.45 [95% confidence interval (Cl), 0.28-0.731. A similar finding was observed when the analysis was limited to those using cholesterol-lowering drugs (OR 0.25; 95% Cl, 0.08-0.80). These data provide support for an inverse relationship between high cholesterol levels and ICH. When considered together with previous findings, in which low cholesterol levels have been associated with an increased risk of haemorrhagic stroke, these data provide evidence that this inverse relationship may extend into a higher range of cholesterol values.
AB - To determine whether a relationship exists between high cholesterol levels and intracerebral haemorrhage (ICH) a case-control study was undertaken on 331 consecutive cases of first-episode primary ICH, verified by computed tomography, and 331 age- and sex-matched community controls. Using conditional logistic regression the adjusted odds ratio (OR) of ICH among individuals reporting a high cholesterol level was 0.45 [95% confidence interval (Cl), 0.28-0.731. A similar finding was observed when the analysis was limited to those using cholesterol-lowering drugs (OR 0.25; 95% Cl, 0.08-0.80). These data provide support for an inverse relationship between high cholesterol levels and ICH. When considered together with previous findings, in which low cholesterol levels have been associated with an increased risk of haemorrhagic stroke, these data provide evidence that this inverse relationship may extend into a higher range of cholesterol values.
KW - Australia
KW - Case-control
KW - Epidemiology
KW - Intracerebral haemorrhage
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=0036656445&partnerID=8YFLogxK
U2 - 10.1054/jocn.2002.1111
DO - 10.1054/jocn.2002.1111
M3 - Article
C2 - 12217665
AN - SCOPUS:0036656445
VL - 9
SP - 376
EP - 380
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 4
ER -