Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice

I D Blum, Z Patterson, R Khazall, E W Lamont, Mark W Sleeman, Tamas L Horvath, Alfonso Abizaid

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128 Citations (Scopus)

Abstract

Ghrelin, an orexigenic hormone produced by the stomach, is secreted in anticipation of scheduled meals and in correlation with anticipatory locomotor activity. We hypothesized that ghrelin is directly implicated in stimulating locomotor activity in anticipation of scheduled meals. To test this hypothesis, we observed 24 h patterns of locomotor activity in mice with targeted mutations of the ghrelin receptor gene (GHSR KO) and wild-type littermates, all given access to food for 4 h daily for 14 days. While wild type (WT) and GHSR KO mice produced increases in anticipatory locomotor activity, anticipatory locomotor activity in GHSR KO mice was attenuated (P
Original languageEnglish
Pages (from-to)351 - 359
Number of pages9
JournalNeuroscience
Volume164
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

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