Abstract
Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with critical and supporting roles in many disease states and conditions. Its disease associations, myriad functions, receptors, and downstream signaling have been the subject of considerable research, yet many questions remain. Moreover, the relevance of MIF's partially functionally redundant family member, D-dopachrome tautomerase (D-DT), also remains to be further characterized. Here, we discuss recent discoveries demonstrating direct roles of MIF in supporting NLR Family Pyrin Domain-Containing 3 (NRLP3) inflammasome activation, as well as acting as a molecular chaperone for intracellular proteins. These findings may offer new clues to understanding MIF's multiple functions, and assist the development of putative MIF-targeting therapeutics for a variety of pathologies.
| Original language | English |
|---|---|
| Pages (from-to) | 447-462 |
| Number of pages | 16 |
| Journal | Trends in Immunology |
| Volume | 40 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 May 2019 |
Cite this
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Rediscovering MIF : New Tricks for an Old Cytokine. / Harris, James; VanPatten, Sonya; Deen, Nadia S.; Al-Abed, Yousef; Morand, Eric F.
In: Trends in Immunology, Vol. 40, No. 5, 01.05.2019, p. 447-462.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Rediscovering MIF
T2 - New Tricks for an Old Cytokine
AU - Harris, James
AU - VanPatten, Sonya
AU - Deen, Nadia S.
AU - Al-Abed, Yousef
AU - Morand, Eric F.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with critical and supporting roles in many disease states and conditions. Its disease associations, myriad functions, receptors, and downstream signaling have been the subject of considerable research, yet many questions remain. Moreover, the relevance of MIF's partially functionally redundant family member, D-dopachrome tautomerase (D-DT), also remains to be further characterized. Here, we discuss recent discoveries demonstrating direct roles of MIF in supporting NLR Family Pyrin Domain-Containing 3 (NRLP3) inflammasome activation, as well as acting as a molecular chaperone for intracellular proteins. These findings may offer new clues to understanding MIF's multiple functions, and assist the development of putative MIF-targeting therapeutics for a variety of pathologies.
AB - Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with critical and supporting roles in many disease states and conditions. Its disease associations, myriad functions, receptors, and downstream signaling have been the subject of considerable research, yet many questions remain. Moreover, the relevance of MIF's partially functionally redundant family member, D-dopachrome tautomerase (D-DT), also remains to be further characterized. Here, we discuss recent discoveries demonstrating direct roles of MIF in supporting NLR Family Pyrin Domain-Containing 3 (NRLP3) inflammasome activation, as well as acting as a molecular chaperone for intracellular proteins. These findings may offer new clues to understanding MIF's multiple functions, and assist the development of putative MIF-targeting therapeutics for a variety of pathologies.
UR - http://www.scopus.com/inward/record.url?scp=85063759700&partnerID=8YFLogxK
U2 - 10.1016/j.it.2019.03.002
DO - 10.1016/j.it.2019.03.002
M3 - Review Article
AN - SCOPUS:85063759700
VL - 40
SP - 447
EP - 462
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 5
ER -