Redefining the role of syndecans in C. elegans biology

Sandeep Gopal, John Couchman, Roger Pocock

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium regulation in mammals that is conserved in C. elegans. We concluded that calcium regulation is the basic, evolutionarily conserved role for syndecans, which enables them to be integral for multiple cellular functions.
Original languageEnglish
Article numbere1142042
Number of pages7
JournalWorm
Volume5
Issue number1
DOIs
Publication statusPublished - 25 Jan 2016

Keywords

  • calcium
  • HSN
  • neuronal development
  • PVQ
  • sdn-1
  • syndecan
  • trp-1
  • trp-2

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