TY - JOUR
T1 - Recurrent membranous nephropathy after transplantation
T2 - donor antigen and HLA converge in defining risk
AU - Robson, Kate J.
AU - Kitching, A. Richard
PY - 2021/3
Y1 - 2021/3
N2 - Membranous nephropathy, like many forms of glomerulonephritis, is an HLA-associated autoimmune disease that can recur in the transplanted kidney. In this issue of Kidney International, Berchtold and colleagues publish an intriguing and important paper on risk factors for recurrent post-transplant membranous nephropathy due to autoimmunity to PLA2R1. They found that the genetics of both the autoantigen and donor HLA are important determinants of the risk of recurrent disease in the graft.
AB - Membranous nephropathy, like many forms of glomerulonephritis, is an HLA-associated autoimmune disease that can recur in the transplanted kidney. In this issue of Kidney International, Berchtold and colleagues publish an intriguing and important paper on risk factors for recurrent post-transplant membranous nephropathy due to autoimmunity to PLA2R1. They found that the genetics of both the autoantigen and donor HLA are important determinants of the risk of recurrent disease in the graft.
UR - http://www.scopus.com/inward/record.url?scp=85101116805&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2020.10.044
DO - 10.1016/j.kint.2020.10.044
M3 - Comment / Debate
AN - SCOPUS:85101116805
SN - 0085-2538
VL - 99
SP - 545
EP - 548
JO - Kidney International
JF - Kidney International
IS - 3
ER -