Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Su Yin Lim; Alex N. Gordon-Weeks; Lei Zhao; Thomas T. Tapmeier; Jae Hong Im; Yunhong Cao; John Beech; Danny Allen; Sean Smart; Ruth J. Muschel

doi:10.4161/onci.23187

Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Su Yin Lim, Alex N. Gordon-Weeks, Lei Zhao, Thomas T. Tapmeier, Jae Hong Im, Yunhong Cao, John Beech, Danny Allen, Sean Smart, Ruth J. Muschel

Research output: Contribution to journal › Article › Other › peer-review

13 Citations (Scopus)

Abstract

Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1^mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

Original language	English
Article number	e23187
Number of pages	3
Journal	OncoImmunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/onci.23187
Publication status	Published - 1 Mar 2013
Externally published	Yes

Keywords

CCL2
Colon cancer
Liver metastasis
Myeloid cell recruitment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.23187

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title = "Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis",

abstract = "Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.",

keywords = "CCL2, Colon cancer, Liver metastasis, Myeloid cell recruitment",

author = "Lim, {Su Yin} and Gordon-Weeks, {Alex N.} and Lei Zhao and Tapmeier, {Thomas T.} and Im, {Jae Hong} and Yunhong Cao and John Beech and Danny Allen and Sean Smart and Muschel, {Ruth J.}",

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T1 - Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

AU - Lim, Su Yin

AU - Gordon-Weeks, Alex N.

AU - Zhao, Lei

AU - Tapmeier, Thomas T.

AU - Im, Jae Hong

AU - Cao, Yunhong

AU - Beech, John

AU - Allen, Danny

AU - Smart, Sean

AU - Muschel, Ruth J.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

AB - Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

KW - CCL2

KW - Colon cancer

KW - Liver metastasis

KW - Myeloid cell recruitment

UR - http://www.scopus.com/inward/record.url?scp=84886944431&partnerID=8YFLogxK

U2 - 10.4161/onci.23187

DO - 10.4161/onci.23187

M3 - Article

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VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 3

M1 - e23187

ER -

Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Abstract

Keywords

UN SDGs

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A macrophage is a macrophage is a macrophage-in metastasis

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