Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Su Yin Lim, Alex N. Gordon-Weeks, Lei Zhao, Thomas T. Tapmeier, Jae Hong Im, Yunhong Cao, John Beech, Danny Allen, Sean Smart, Ruth J. Muschel

Research output: Contribution to journalArticleOtherpeer-review

11 Citations (Scopus)

Abstract

Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

Original languageEnglish
Article numbere23187
Number of pages3
JournalOncoImmunology
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013
Externally publishedYes

Keywords

  • CCL2
  • Colon cancer
  • Liver metastasis
  • Myeloid cell recruitment

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