Reconstituted HDL: A therapy for atherosclerosis and beyond

Andrew J. Murphy, Jaye Chin-Dusting, Dmitri Sviridov

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of death in developed countries. As low levels of the cardioprotective particle HDL are associated with cardiovascular disease, raising HDL levels may lead to positive outcomes. Reconstituted HDL (rHDL) therapy in humans has resulted in regression of atheroma volume and plaque remodeling. The applications of rHDL appear vast as encouraging results in improving glucose uptake and insulin levels have also been reported in Type 2 diabetics. The potent anti-inflammatory properties of rHDL can also be exploited to reduce inflammation is diseases such as rheumatoid arthritis. Furthermore, as HDL is an inert particle, it may also have applications in drug delivery. This paper discusses the results obtained to date with rHDL therapy and provides an outlook into the future in regards to potential uses.

Original languageEnglish
Pages (from-to)731-739
Number of pages9
JournalClinical Lipidology
Volume4
Issue number6
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Diabetes
  • Diagnostic
  • Drug delivery
  • Inflammation
  • Reconstituted HDL

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