Recommendations for the prevention of pregnancy-associated venous thromboembolism

Claire McLintock, Tim Brighton, Sanjeev Chunilal, Gustaaf Dekker, Nolan McDonnell, Simon McRae, Peter Muller, Huyen Tran, Barry Walters, Laura Young

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Abstract

Pregnancy is a risk factor for venous thromboembolism (VTE), an important cause of maternal morbidity and mortality. Although there is a 4-5-fold increased risk compared to that of nonpregnant women of the same age, the absolute risk is low at no more than two episodes of VTE per 1000 pregnancies. There is uncertainty about which women require thromboprophylaxis during pregnancy or postpartum because of a lack of data from appropriate clinical trials. For this reason, recommendations for prophylaxis should be made only after explaining the available evidence to the patient and taking into account her perception of the balance of risk and benefit in thromboprophylaxis. The aim of these recommendations is to provide clinicians with practical advice to assist in decisions regarding thromboprophylaxis in women considered to be at risk of VTE during pregnancy and the postpartum. The authors are clinicians from across New Zealand and Australia representing the fields of haematology, obstetric medicine, anaesthesiology, maternal-fetal medicine and obstetrics. Authors were invited to review the relevant literature and then worked collaboratively to devise recommendations and resolve areas of controversy. The recommendations contained herein were reached by consensus and represent the opinion of the panel. The absence of randomised clinical trials in this area limits the strength of evidence that can be used, and it is acknowledged that they represent level C evidence. The panel advocates for appropriate clinical studies to be carried out in this patient population to address the inadequacy of present evidence. A? 2011 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Original languageEnglish
Pages (from-to)3 - 13
Number of pages11
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Volume52
Issue number1
DOIs
Publication statusPublished - 2012

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