Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge

Fabiana K Seixas; Everton F da Silva; Daiane D Hartwig; Gustavo M Cerqueira; Marta Amaral; Michel Q Fagundes; Robson G Dossa; Odir A Dellagostin

doi:10.1016/j.vaccine.2007.10.052

Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge

Fabiana K Seixas, Everton F da Silva, Daiane D Hartwig, Gustavo M Cerqueira, Marta Amaral, Michel Q Fagundes, Robson G Dossa, Odir A Dellagostin

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Abstract

The bacillus Calmette--Guerin (BCG), a live attenuated Mycobacterium bovis strain is considered a promising candidate as a vector system for delivery of foreign antigens to the immune system. The gene coding for the Leptospira interrogans external membrane protein LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG. Hamsters immunized with recombinant BCG (rBCG) expressing LipL32 were protected against mortality (P

Original language	English
Pages (from-to)	88 - 95
Number of pages	8
Journal	Vaccine
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.vaccine.2007.10.052
Publication status	Published - 2007
Externally published	Yes

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10.1016/j.vaccine.2007.10.052

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title = "Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge",

abstract = "The bacillus Calmette--Guerin (BCG), a live attenuated Mycobacterium bovis strain is considered a promising candidate as a vector system for delivery of foreign antigens to the immune system. The gene coding for the Leptospira interrogans external membrane protein LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG. Hamsters immunized with recombinant BCG (rBCG) expressing LipL32 were protected against mortality (P",

author = "Seixas, {Fabiana K} and {da Silva}, {Everton F} and Hartwig, {Daiane D} and Cerqueira, {Gustavo M} and Marta Amaral and Fagundes, {Michel Q} and Dossa, {Robson G} and Dellagostin, {Odir A}",

year = "2007",

doi = "10.1016/j.vaccine.2007.10.052",

language = "English",

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T1 - Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge

AU - Seixas, Fabiana K

AU - da Silva, Everton F

AU - Hartwig, Daiane D

AU - Cerqueira, Gustavo M

AU - Amaral, Marta

AU - Fagundes, Michel Q

AU - Dossa, Robson G

AU - Dellagostin, Odir A

PY - 2007

Y1 - 2007

N2 - The bacillus Calmette--Guerin (BCG), a live attenuated Mycobacterium bovis strain is considered a promising candidate as a vector system for delivery of foreign antigens to the immune system. The gene coding for the Leptospira interrogans external membrane protein LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG. Hamsters immunized with recombinant BCG (rBCG) expressing LipL32 were protected against mortality (P

AB - The bacillus Calmette--Guerin (BCG), a live attenuated Mycobacterium bovis strain is considered a promising candidate as a vector system for delivery of foreign antigens to the immune system. The gene coding for the Leptospira interrogans external membrane protein LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG. Hamsters immunized with recombinant BCG (rBCG) expressing LipL32 were protected against mortality (P

UR - http://www.ncbi.nlm.nih.gov/pubmed/18063449

U2 - 10.1016/j.vaccine.2007.10.052

DO - 10.1016/j.vaccine.2007.10.052

M3 - Article

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SP - 88

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JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 1

ER -

Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge

Abstract

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