Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge

Fabiana K Seixas, Everton F da Silva, Daiane D Hartwig, Gustavo M Cerqueira, Marta Amaral, Michel Q Fagundes, Robson G Dossa, Odir A Dellagostin

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)


The bacillus Calmette--Guerin (BCG), a live attenuated Mycobacterium bovis strain is considered a promising candidate as a vector system for delivery of foreign antigens to the immune system. The gene coding for the Leptospira interrogans external membrane protein LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG. Hamsters immunized with recombinant BCG (rBCG) expressing LipL32 were protected against mortality (P
Original languageEnglish
Pages (from-to)88 - 95
Number of pages8
Issue number1
Publication statusPublished - 2007
Externally publishedYes

Cite this