Recombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis

R. I. McLachlan, K. D. Dahl, W. J. Bremner, R. Schwall, C. H. Schmelzer, A. J. Mason, R. A. Steiner

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Activin-A is a homodimer of the β(A) inhibin subunit that stimulates FSH secretion by pituitary cells in vitro; however, the physiological relevance of this effect is unknown. We have examined whether recombinant human activin-A (activin-A; 80 μg/kg/day iv infusion for 50.5 h) has in vivo bioactivity in the adult male macaque (n = 5). Serum FSH and LH bioactivity and serum testosterone (T) levels were measured on 2 control days and after 24 and 48 h of activin-A administration. Basal FSH levels increased significantly (p <0.05) by 17% at 24 h and 82% at 48 h during activin-A administration. No changes in basal LH or T levels were seen. The FSH and LH responses to GnRH (5 μg/kg, iv bolus) increased significantly (p <0.05) by 117% and 55% after 48 h of activin-A, respectively. A small (16%), but statistically significant (p <0.05), increase in the T response to the GnRH challenge was also noted. These data are preliminary evidence in support of a physiological role for activin-A in the control of gonadotropin secretion in the male primate.

Original languageEnglish
Pages (from-to)2787-2789
Number of pages3
Issue number5
Publication statusPublished - 1989
Externally publishedYes

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