Recognition of CD1d-restricted antigens by natural killer T cells

Jamie Rossjohn; Daniel G Pellicci; Onisha G Patel; Laurent Gapin; Dale I Godfrey

doi:10.1038/nri3328

Recognition of CD1d-restricted antigens by natural killer T cells

Jamie Rossjohn, Daniel G Pellicci, Onisha G Patel, Laurent Gapin, Dale I Godfrey

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

376 Citations (Scopus)

Abstract

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines following T cell receptor (TCR) activation and can shape the immune response in many different settings. There are two main NKT cell subsets: type I NKT cells are typically characterized by the expression of a semi-invariant TCR, whereas the TCRs expressed by type II NKT cells are more diverse. This Review focuses on the defining features and emerging generalities regarding how NKT cells specifically recognize self, microbial and synthetic lipid-based antigens that are presented by CD1d. Such information is vitally important to better understand, and fully harness, the therapeutic potential of NKT cells.

Original language	English
Pages (from-to)	845 - 857
Number of pages	13
Journal	Nature Reviews Immunology
Volume	12
Issue number	12
DOIs	https://doi.org/10.1038/nri3328
Publication status	Published - 2012

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10.1038/nri3328

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Recognition of CD1d-restricted antigens by natural killer T cells

Abstract

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