Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly

B. J. Zeng, Yap Pang Chuan, B. O'Sullivan, I. Caminschi, M. H. Lahoud, R. Thomas, A. P J Middelberg

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

A new class of targeted and immune-evading nanocarrier made using only biological components and facile processes is assembled in a bottom-up fashion. Simple top-down sequential addition of immune-evading or receptor-specific antibody elements conjugated to biosurfactant protein DAMP4 promotes self-assembly at an interface previously formed in the presence of peptide surfactant AM1, leading to a functional display at the interface through non-covalent molecular self-assembly. 

Original languageEnglish
Pages (from-to)3736-3742
Number of pages7
JournalSmall
Volume9
Issue number22
DOIs
Publication statusPublished - 25 Nov 2013
Externally publishedYes

Keywords

  • antigens
  • dendritic cells
  • drug delivery
  • proteins
  • receptor specific
  • targeted delivery

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