Receptor protein complexes are in control of autophagy

Dalibor Mijaljica, Taras Y Nazarko, John H Brumell, Wei-Pang Huang, Masaaki Komatsu, Mark Prescott, Anne Simonsen, Ai Yamamoto, Hong Zhang, Daniel J Klionsky, Rodney J Devenish

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

In autophagic processes a variety of cargos is delivered to the degradative compartment of cells. Recent progress in autophagy research has provided support for the notion that when autophagic processes are operating in selective mode, a receptor protein complex will process the cargo. Here we present a concept of receptor protein complexes as comprising a functional tetrad of components: a ligand, a receptor, a scaffold and an Atg8 family protein. Our current understanding of each of the four components and their interaction in the context of cargo selection are considered in turn.
Original languageEnglish
Pages (from-to)1701 - 1705
Number of pages5
JournalAutophagy
Volume8
Issue number11
DOIs
Publication statusPublished - 2012

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