Receptor activity modifying proteins and their potential as drug targets

Denise Wootten, John Watson Simms, Debbie L Hay, Arthur Christopoulos, Patrick Sexton

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

8 Citations (Scopus)

Abstract

The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.
Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
EditorsC A Lunn
Place of PublicationUK
PublisherAcademic Press
Pages53 - 79
Number of pages27
Edition1st
ISBN (Print)1877-1173
DOIs
Publication statusPublished - 2010

Cite this