Receptor activity modifying proteins and their potential as drug targets

Denise Wootten; John Watson Simms; Debbie L Hay; Arthur Christopoulos; Patrick Sexton

doi:10.1016/S1877-1173(10)91003-X

Receptor activity modifying proteins and their potential as drug targets

Denise Wootten, John Watson Simms, Debbie L Hay, Arthur Christopoulos, Patrick Sexton

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

10 Citations (Scopus)

Abstract

The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

Original language	English
Title of host publication	Progress in Molecular Biology and Translational Science
Editors	C A Lunn
Place of Publication	UK
Publisher	Academic Press
Pages	53 - 79
Number of pages	27
Edition	1st
DOIs	https://doi.org/10.1016/S1877-1173(10)91003-X
Publication status	Published - 2010

Access to Document

10.1016/S1877-1173(10)91003-X

Cite this

@inbook{e3cdc12fb4c54c1a9c78d42cb7bb641f,

title = "Receptor activity modifying proteins and their potential as drug targets",

abstract = "The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.",

author = "Denise Wootten and Simms, {John Watson} and Hay, {Debbie L} and Arthur Christopoulos and Patrick Sexton",

year = "2010",

doi = "10.1016/S1877-1173(10)91003-X",

language = "English",

pages = "53 -- 79",

editor = "Lunn, {C A}",

booktitle = "Progress in Molecular Biology and Translational Science",

publisher = "Academic Press",

address = "United States of America",

edition = "1st",

}

TY - CHAP

T1 - Receptor activity modifying proteins and their potential as drug targets

AU - Wootten, Denise

AU - Simms, John Watson

AU - Hay, Debbie L

AU - Christopoulos, Arthur

AU - Sexton, Patrick

PY - 2010

Y1 - 2010

N2 - The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

AB - The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many years. RAMPs therefore provide a new avenue for drug development, offering opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. RAMPs could be directly targeted themselves or advantage could be taken of the unique RAMP/GPCR interfaces for generating more selective drugs.

U2 - 10.1016/S1877-1173(10)91003-X

DO - 10.1016/S1877-1173(10)91003-X

M3 - Chapter (Book)

SP - 53

EP - 79

BT - Progress in Molecular Biology and Translational Science

A2 - Lunn, C A

PB - Academic Press

CY - UK

ER -