Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery

Sze Shin Low, Chang Nong Lim, Maxine Yew, Wai Siong Chai, Liang Ee Low, Sivakumar Manickam, Beng Ti Tey, Pau Loke Show

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51 Citations (Scopus)


Recent advances in ultrasound (US) have shown its great potential in biomedical applications as diagnostic and therapeutic tools. The coupling of US-assisted drug delivery systems with nanobiomaterials possessing tailor-made functions has been shown to remove the limitations of conventional drug delivery systems. The low-frequency US has significantly enhanced the targeted drug delivery effect and efficacy, reducing limitations posed by conventional treatments such as a limited therapeutic window. The acoustic cavitation effect induced by the ultrasound-mediated microbubbles (MBs) has been reported to replace drugs in certain acute diseases like ischemic stroke. This review briefly discusses the ultrasound principles, with particular attention to the recent advancements in drug delivery applications. Furthermore, US-assisted drug delivery coupled with nanobiomaterials to treat different diseases (cancer, neurodegenerative disease, diabetes, thrombosis and COVID-19) are discussed in detail. Finally, this review covers the future perspectives and challenges on the applications of US-mediated nanobiomaterials.

Original languageEnglish
Article number105805
Number of pages23
JournalUltrasonics Sonochemistry
Publication statusPublished - Dec 2021


  • COVID-19
  • Disease
  • Drug delivery
  • Nanobiomaterial
  • Ultrasound

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