Recent trends in early stage response to combination antiretroviral therapy in Australia

Hamish McManus, Jennifer Frances Hoy, Ian John Woolley, Mark Alastair Boyd, Mark D Kelly, Brian P Mulhall, Norman J Roth, Kathy Petoumenos, Matthew G Law

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


Background: There have been improvements in combination antiretroviral therapy (cART) over the past 15 years. The aim of this analysis was to assess whether improvements in ART have resulted in improvements in surrogates of HIV outcome. Methods: Patients in the Australian HIV Observational Database who initiated treatment using mono/duo therapy prior to 1996, or using cART from 1996 onwards, were included in the analysis. Patients were stratified by era of ART initiation. Median changes in CD4+ T-cell count and the proportion of patients with detectable HIV viral load (>400 copies/ml) were calculated over the first 4 years of treatment. Probabilities of treatment switch were estimated using the Kaplan-Meier method. Results: A total of 2,753 patients were included in the analysis: 28 initiated treatment
Original languageEnglish
Pages (from-to)131 - 139
Number of pages9
JournalAntiviral Therapy
Issue number2
Publication statusPublished - 2015

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