Recent trends in early stage response to combination antiretroviral therapy in Australia

Hamish McManus; Jennifer Frances Hoy; Ian John Woolley; Mark Alastair Boyd; Mark D Kelly; Brian P Mulhall; Norman J Roth; Kathy Petoumenos; Matthew G Law

doi:10.3851/IMP2774

Recent trends in early stage response to combination antiretroviral therapy in Australia

Hamish McManus, Jennifer Frances Hoy, Ian John Woolley, Mark Alastair Boyd, Mark D Kelly, Brian P Mulhall, Norman J Roth, Kathy Petoumenos, Matthew G Law

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Background: There have been improvements in combination antiretroviral therapy (cART) over the past 15 years. The aim of this analysis was to assess whether improvements in ART have resulted in improvements in surrogates of HIV outcome. Methods: Patients in the Australian HIV Observational Database who initiated treatment using mono/duo therapy prior to 1996, or using cART from 1996 onwards, were included in the analysis. Patients were stratified by era of ART initiation. Median changes in CD4+ T-cell count and the proportion of patients with detectable HIV viral load (>400 copies/ml) were calculated over the first 4 years of treatment. Probabilities of treatment switch were estimated using the Kaplan-Meier method. Results: A total of 2,753 patients were included in the analysis: 28 initiated treatment

Original language	English
Pages (from-to)	131 - 139
Number of pages	9
Journal	Antiviral Therapy
Volume	20
Issue number	2
DOIs	https://doi.org/10.3851/IMP2774
Publication status	Published - 2015

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title = "Recent trends in early stage response to combination antiretroviral therapy in Australia",

abstract = "Background: There have been improvements in combination antiretroviral therapy (cART) over the past 15 years. The aim of this analysis was to assess whether improvements in ART have resulted in improvements in surrogates of HIV outcome. Methods: Patients in the Australian HIV Observational Database who initiated treatment using mono/duo therapy prior to 1996, or using cART from 1996 onwards, were included in the analysis. Patients were stratified by era of ART initiation. Median changes in CD4+ T-cell count and the proportion of patients with detectable HIV viral load (>400 copies/ml) were calculated over the first 4 years of treatment. Probabilities of treatment switch were estimated using the Kaplan-Meier method. Results: A total of 2,753 patients were included in the analysis: 28 initiated treatment",

author = "Hamish McManus and Hoy, {Jennifer Frances} and Woolley, {Ian John} and Boyd, {Mark Alastair} and Kelly, {Mark D} and Mulhall, {Brian P} and Roth, {Norman J} and Kathy Petoumenos and Law, {Matthew G}",

year = "2015",

doi = "10.3851/IMP2774",

language = "English",

volume = "20",

pages = "131 -- 139",

journal = "Antiviral Therapy",

issn = "1359-6535",

publisher = "International Medical Press",

number = "2",

}

TY - JOUR

T1 - Recent trends in early stage response to combination antiretroviral therapy in Australia

AU - McManus, Hamish

AU - Hoy, Jennifer Frances

AU - Woolley, Ian John

AU - Boyd, Mark Alastair

AU - Kelly, Mark D

AU - Mulhall, Brian P

AU - Roth, Norman J

AU - Petoumenos, Kathy

AU - Law, Matthew G

PY - 2015

Y1 - 2015

N2 - Background: There have been improvements in combination antiretroviral therapy (cART) over the past 15 years. The aim of this analysis was to assess whether improvements in ART have resulted in improvements in surrogates of HIV outcome. Methods: Patients in the Australian HIV Observational Database who initiated treatment using mono/duo therapy prior to 1996, or using cART from 1996 onwards, were included in the analysis. Patients were stratified by era of ART initiation. Median changes in CD4+ T-cell count and the proportion of patients with detectable HIV viral load (>400 copies/ml) were calculated over the first 4 years of treatment. Probabilities of treatment switch were estimated using the Kaplan-Meier method. Results: A total of 2,753 patients were included in the analysis: 28 initiated treatment

AB - Background: There have been improvements in combination antiretroviral therapy (cART) over the past 15 years. The aim of this analysis was to assess whether improvements in ART have resulted in improvements in surrogates of HIV outcome. Methods: Patients in the Australian HIV Observational Database who initiated treatment using mono/duo therapy prior to 1996, or using cART from 1996 onwards, were included in the analysis. Patients were stratified by era of ART initiation. Median changes in CD4+ T-cell count and the proportion of patients with detectable HIV viral load (>400 copies/ml) were calculated over the first 4 years of treatment. Probabilities of treatment switch were estimated using the Kaplan-Meier method. Results: A total of 2,753 patients were included in the analysis: 28 initiated treatment

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185258/

U2 - 10.3851/IMP2774

DO - 10.3851/IMP2774

M3 - Article

VL - 20

SP - 131

EP - 139

JO - Antiviral Therapy

JF - Antiviral Therapy

SN - 1359-6535

IS - 2

ER -

Recent trends in early stage response to combination antiretroviral therapy in Australia

Abstract

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