Recent progress in nanomaterial-based electrochemical and optical sensors for hypoxanthine and xanthine. A review

Muamer Dervisevic, Esma Dervisevic, Mehmet Şenel

Research output: Contribution to journalReview ArticleResearchpeer-review

47 Citations (Scopus)


This review (with 160 ref.) summarizes the progress that has been made in the methods for chemical or biochemical sensing of hypoxanthine and xanthine, which are produced as part of purine metabolism and are precursors of uric acid. An introduction discusses the importance of hypoxanthine and xanthine as analytes due to their significance in the clinical and food science, together with the conventional methods of analysis. A large section covers methods for the electrochemical hypoxanthine and xanthine sensing. It is divided into subsections according to the nanomaterials used including carbon nanomaterials, meal oxide nanoparticles, metal organic frameworks, conductive polymers, and bio-nanocomposites. A further large section covers optical methods for hypoxanthine and xanthine sensing, with subsections on nanomaterials including carbon nanomaterials, nanosheets, nanoclusters, nanoparticles, and their bio-nanocomposites. A concluding section summarizes the current status, addresses current challenges, and discusses future perspectives. [Figure not available: see fulltext.].

Original languageEnglish
Article number749
Number of pages25
JournalMicrochimica Acta
Issue number12
Publication statusPublished - 1 Dec 2019


  • ATP degradation
  • Food quality
  • Hyperuricemia
  • Meat freshness
  • Nanotechnology
  • Nonenzymatic sensors
  • Purine metabolism
  • Xanthine oxidase
  • Xanthinuria

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