Recent progress in lab-on-a-chip systems for the monitoring of metabolites for mammalian and microbial cell research

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Abstract

Lab-on-a-chip sensing technologies have changed how cell biology research is conducted. This review summarises the progress in the lab-on-a-chip devices implemented for the detection of cellular metabolites. The review is divided into two subsections according to the methods used for the metabolite detection. Each section includes a table which summarises the relevant literature and also elaborates the advantages of, and the challenges faced with that particular method. The review continues with a section discussing the achievements attained due to using lab-on-a-chip devices within the specific context. Finally, a concluding section summarises what is to be resolved and discusses the future perspectives.

Original languageEnglish
Article number5027
Number of pages36
JournalSensors (Switzerland)
Volume19
Issue number22
DOIs
Publication statusPublished - 18 Nov 2019

Keywords

  • Bioprocess monitoring
  • Cell culture
  • Continuous monitoring
  • Extracellular metabolites
  • High throughput analysis
  • Intracellular metabolites
  • Microfluidic devices
  • Optical and electrochemical metabolite sensing

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