Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Diabetes is considered a major burden on the healthcare system of Western and non-Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro- and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism-based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.

Original languageEnglish
Article numbere1016
Number of pages20
JournalClinical and Translational Immunology
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • cardiovascular disease
  • chronic kidney disease
  • diabetes
  • inflammation
  • oxidative stress
  • retinopathy

Cite this

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title = "Recent novel approaches to limit oxidative stress and inflammation in diabetic complications",
abstract = "Diabetes is considered a major burden on the healthcare system of Western and non-Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro- and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism-based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.",
keywords = "cardiovascular disease, chronic kidney disease, diabetes, inflammation, oxidative stress, retinopathy",
author = "Pickering, {Raelene J.} and Rosado, {Carlos J.} and Arpeeta Sharma and Shareefa Buksh and Mitchel Tate and {de Haan}, {Judy B.}",
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Recent novel approaches to limit oxidative stress and inflammation in diabetic complications. / Pickering, Raelene J.; Rosado, Carlos J.; Sharma, Arpeeta; Buksh, Shareefa; Tate, Mitchel; de Haan, Judy B.

In: Clinical and Translational Immunology, Vol. 7, No. 4, e1016, 01.01.2018.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Pickering, Raelene J.

AU - Rosado, Carlos J.

AU - Sharma, Arpeeta

AU - Buksh, Shareefa

AU - Tate, Mitchel

AU - de Haan, Judy B.

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Y1 - 2018/1/1

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AB - Diabetes is considered a major burden on the healthcare system of Western and non-Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro- and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism-based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.

KW - cardiovascular disease

KW - chronic kidney disease

KW - diabetes

KW - inflammation

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