TY - JOUR
T1 - Recent insights into humoral and cellular immune responses against malaria
AU - Beeson, James G.
AU - Osier, Faith H.A.
AU - Engwerda, Christian R.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Effective immunity to malaria has been clearly demonstrated among individuals naturally exposed to malaria, and can be induced by experimental infections in animals and humans. The large number of malaria antigens has presented a major challenge to identifying protective responses and their targets, and it is likely that robust immunity is mediated by responses to multiple antigens. These include merozoite surface antigens and invasion ligands, variant antigens on the surface of parasitized red blood cells, in addition to sporozoite and liver-stage antigens. Immunity seems to require humoral and cellular immune components, probably in co-operation, although the relative importance of each remains unclear. This review summarizes recent progress towards understanding the targets and mechanisms that are important for mediating immunity to malaria.
AB - Effective immunity to malaria has been clearly demonstrated among individuals naturally exposed to malaria, and can be induced by experimental infections in animals and humans. The large number of malaria antigens has presented a major challenge to identifying protective responses and their targets, and it is likely that robust immunity is mediated by responses to multiple antigens. These include merozoite surface antigens and invasion ligands, variant antigens on the surface of parasitized red blood cells, in addition to sporozoite and liver-stage antigens. Immunity seems to require humoral and cellular immune components, probably in co-operation, although the relative importance of each remains unclear. This review summarizes recent progress towards understanding the targets and mechanisms that are important for mediating immunity to malaria.
UR - http://www.scopus.com/inward/record.url?scp=55549094399&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2008.08.008
DO - 10.1016/j.pt.2008.08.008
M3 - Review Article
C2 - 18848497
AN - SCOPUS:55549094399
SN - 1471-4922
VL - 24
SP - 578
EP - 584
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 12
ER -
