Recent insights into humoral and cellular immune responses against malaria

James G. Beeson, Faith H.A. Osier, Christian R. Engwerda

Research output: Contribution to journalReview ArticleResearchpeer-review

95 Citations (Scopus)


Effective immunity to malaria has been clearly demonstrated among individuals naturally exposed to malaria, and can be induced by experimental infections in animals and humans. The large number of malaria antigens has presented a major challenge to identifying protective responses and their targets, and it is likely that robust immunity is mediated by responses to multiple antigens. These include merozoite surface antigens and invasion ligands, variant antigens on the surface of parasitized red blood cells, in addition to sporozoite and liver-stage antigens. Immunity seems to require humoral and cellular immune components, probably in co-operation, although the relative importance of each remains unclear. This review summarizes recent progress towards understanding the targets and mechanisms that are important for mediating immunity to malaria.

Original languageEnglish
Pages (from-to)578-584
Number of pages7
JournalTrends in Parasitology
Issue number12
Publication statusPublished - 1 Dec 2008
Externally publishedYes

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