Recent developments in metabolomics studies of endophytic fungi

Kashvintha Nagarajan, Baharudin Ibrahim, Abdulkader Ahmad Bawadikji, Jun-Wei Lim, Woei-Yenn Tong, Chean-Ring Leong, Kooi Yeong Khaw, Wen-Nee Tan

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)


Endophytic fungi are microorganisms that colonize living plants’ tissues without causing any harm. They are known as a natural source of bioactive metabolites with diverse pharmacological functions. Many structurally different chemical metabolites were isolated from endophytic fungi. Recently, the increasing trends in human health problems and diseases have escalated the search for bioactive metabolites from endophytic fungi. The conventional bioassay-guided study is known as laborious due to chemical complexity. Thus, metabolomics studies have attracted extensive research interest owing to their potential in dealing with a vast number of metabolites. Metabolomics coupled with advanced analytical tools provides a comprehensive insight into systems biology. Despite its wide scientific attention, endophytic fungi metabolomics are relatively unexploited. This review highlights the recent developments in metabolomics studies of endophytic fungi in obtaining the global metabolites picture.

Original languageEnglish
Article number28
Number of pages14
JournalJournal of Fungi
Issue number1
Publication statusPublished - Jan 2022


  • Analytical tool
  • Bioactive metabolites
  • Endophytic fungi
  • Extraction
  • Liquid chromatography–high-resolution mass spectrometry
  • Metabolomics
  • Nuclear magnetic resonance
  • Systems biology

Cite this