Recent Clinical Developments in Alzheimer’s Disease

Xin Yi Choo, Alexandra Grubman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Alzheimer’s disease is the most common neurodegenerative disease. Despite intensive research, promising therapies have failed to translate to the clinic. This chapter will review the prevailing mechanistic hypotheses to explain AD pathogenesis, including the cholinergic, amyloid-cascade, inflammatory and metal dyshomeostasis theories, present an update on the clinical developments in therapies targeting each of the hypotheses, and highlight promising areas requiring further research.
Original languageEnglish
Title of host publicationFrontiers in Clinical Drug Research
Subtitle of host publicationAlzheimer Disorders
EditorsAtta-ur-Rahman
Place of PublicationUnited Arab Emirates
PublisherBentham Science Publishers
Pages3-64
Number of pages62
Volume5
ISBN (Electronic)9781681082318
ISBN (Print)9781681082325
DOIs
Publication statusPublished - 2016
Externally publishedYes

Publication series

NameFrontiers in Clinical Drug Research - Alzheimer Disorders
PublisherBentham Science Publishers
ISSN (Print)2451-8743
ISSN (Electronic)2214-5168

Keywords

  • Alzheimer’s disease
  • Amyloid antibodies
  • Amyloid cascade hypothesis
  • Cholinergic hypothesis
  • Clinical trials
  • COX inhibitors
  • Familial
  • Metal homeostasis
  • Metal ionophores
  • Multi-targeting
  • Neuroinflammation
  • Secretase modulators
  • Sporadic

Cite this

Choo, X. Y., & Grubman, A. (2016). Recent Clinical Developments in Alzheimer’s Disease. In A-R. (Ed.), Frontiers in Clinical Drug Research : Alzheimer Disorders (Vol. 5, pp. 3-64). (Frontiers in Clinical Drug Research - Alzheimer Disorders). United Arab Emirates: Bentham Science Publishers. https://doi.org/10.2174/97816080572211130101
Choo, Xin Yi ; Grubman, Alexandra. / Recent Clinical Developments in Alzheimer’s Disease. Frontiers in Clinical Drug Research : Alzheimer Disorders. editor / Atta-ur-Rahman. Vol. 5 United Arab Emirates : Bentham Science Publishers, 2016. pp. 3-64 (Frontiers in Clinical Drug Research - Alzheimer Disorders).
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keywords = "Alzheimer’s disease, Amyloid antibodies, Amyloid cascade hypothesis, Cholinergic hypothesis, Clinical trials, COX inhibitors, Familial, Metal homeostasis, Metal ionophores, Multi-targeting, Neuroinflammation, Secretase modulators, Sporadic",
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Choo, XY & Grubman, A 2016, Recent Clinical Developments in Alzheimer’s Disease. in A-R (ed.), Frontiers in Clinical Drug Research : Alzheimer Disorders. vol. 5, Frontiers in Clinical Drug Research - Alzheimer Disorders, Bentham Science Publishers, United Arab Emirates, pp. 3-64. https://doi.org/10.2174/97816080572211130101

Recent Clinical Developments in Alzheimer’s Disease. / Choo, Xin Yi; Grubman, Alexandra.

Frontiers in Clinical Drug Research : Alzheimer Disorders. ed. / Atta-ur-Rahman. Vol. 5 United Arab Emirates : Bentham Science Publishers, 2016. p. 3-64 (Frontiers in Clinical Drug Research - Alzheimer Disorders).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Choo XY, Grubman A. Recent Clinical Developments in Alzheimer’s Disease. In A-R, editor, Frontiers in Clinical Drug Research : Alzheimer Disorders. Vol. 5. United Arab Emirates: Bentham Science Publishers. 2016. p. 3-64. (Frontiers in Clinical Drug Research - Alzheimer Disorders). https://doi.org/10.2174/97816080572211130101