Recent Clinical Developments in Alzheimer’s Disease

Xin Yi Choo, Alexandra Grubman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Alzheimer’s disease is the most common neurodegenerative disease. Despite intensive research, promising therapies have failed to translate to the clinic. This chapter will review the prevailing mechanistic hypotheses to explain AD pathogenesis, including the cholinergic, amyloid-cascade, inflammatory and metal dyshomeostasis theories, present an update on the clinical developments in therapies targeting each of the hypotheses, and highlight promising areas requiring further research.
Original languageEnglish
Title of host publicationFrontiers in Clinical Drug Research
Subtitle of host publicationAlzheimer Disorders
Place of PublicationUnited Arab Emirates
PublisherBentham Science Publishers
Number of pages62
ISBN (Electronic)9781681082318
ISBN (Print)9781681082325
Publication statusPublished - 2016
Externally publishedYes

Publication series

NameFrontiers in Clinical Drug Research - Alzheimer Disorders
PublisherBentham Science Publishers
ISSN (Print)2451-8743
ISSN (Electronic)2214-5168


  • Alzheimer’s disease
  • Amyloid antibodies
  • Amyloid cascade hypothesis
  • Cholinergic hypothesis
  • Clinical trials
  • COX inhibitors
  • Familial
  • Metal homeostasis
  • Metal ionophores
  • Multi-targeting
  • Neuroinflammation
  • Secretase modulators
  • Sporadic

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