Recent applications of instrumental biosensors for protein and peptide structure-function studies

Since the introduction in the early 1990's of a novel biosensor technology that measures changes in refractive index at or near a sensor surface, the technique has been rapidly embraced by the biological research community to measure a wide range of biomolecular interactions. We will review some recent applications of this technology including preparative ligand fishing and cell-based studies, and discuss the relative merits of different instruments for various applications.