Recent Advances on Luminescent Enhancement-Based Porous Silicon Biosensors

S. N. Aisyiyah Jenie , Sally E. Plush, Nicolas H. Voelcker

Research output: Contribution to journalReview ArticleResearchpeer-review

33 Citations (Scopus)


Luminescence–based detection paradigms have key advantages over other optical platforms such as absorbance, reflectance or interferometric based detection. However, autofluorescence, low quantum yield and lack of photostability of the fluorophore or emitting molecule are still performance-limiting factors. Recent research has shown the need for enhanced luminescence-based detection to overcome these drawbacks while at the same time improving the sensitivity, selectivity and reducing the detection limits of optical sensors and biosensors. Nanostructures have been reported to significantly improve the spectral properties of the emitting molecules. These structures offer unique electrical, optic and magnetic properties which may be used to tailor the surrounding electrical field of the emitter. Here, the main principles behind luminescence and luminescence enhancement-based detections are reviewed, with an emphasis on europium complexes as the emitting molecule. An overview of the optical porous silicon microcavity (pSiMC) as a biosensing platform and recent proof-of-concept examples on enhanced luminescence-based detection using pSiMCs are provided and discussed.

Original languageEnglish
Pages (from-to)2314-2336
Number of pages23
JournalPharmaceutical Research
Issue number10
Publication statusPublished - 1 Oct 2016
Externally publishedYes


  • biosensors
  • europium
  • luminescence enhancement
  • microcavity
  • porous silicon

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