Recent advances in the understanding of severe cutaneous adverse reactions

N.R. Adler, A.K. Aung, E.N. Ergen, J. Trubiano, M.S.Y. Goh, E.J. Phillips

Research output: Contribution to journalReview ArticleResearchpeer-review


Severe cutaneous adverse reactions (SCARs) encompass a heterogeneous group of delayed hypersensitivity reactions, which are most frequently caused by drugs. Our understanding of several aspects of SCAR syndromes has evolved considerably over the previous decade. This review explores evolving knowledge on the immunopathogenic mechanisms, pharmacogenomic associations, in-vivo and ex-vivo diagnostics for causality assessment and medication cross-reactivity data related to SCAR syndromes. Given the rarity and severity of these diseases, multidisciplinary collaboration through large international, national and/or multicentre networks to collect prospective data on patients with SCAR syndromes should be prioritized. This will further enhance a systematised framework for translating epidemiological, clinical, and immunopathogenetic advances into preventive efforts and improved outcomes for patients.
Original languageEnglish
Pages (from-to)1234-1247
Number of pages14
JournalBritish Journal of Dermatology
Issue number5
Publication statusPublished - Nov 2017

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