Recent advances in dengue pathogenesis and clinical management

Cameron P. Simmons; Kirsty McPherson; Nguyen Van Vinh Chau; D. T. Hoai Tam; Paul Young; Jason Mackenzie; Bridget Wills

doi:10.1016/j.vaccine.2015.09.103

Recent advances in dengue pathogenesis and clinical management

Cameron P. Simmons, Kirsty McPherson, Nguyen Van Vinh Chau, D. T. Hoai Tam, Paul Young, Jason Mackenzie, Bridget Wills

Research output: Contribution to journal › Article › Research › peer-review

64 Citations (Scopus)

Abstract

This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification.

Original language	English
Pages (from-to)	7061-7068
Number of pages	8
Journal	Vaccine
Volume	33
Issue number	50
DOIs	https://doi.org/10.1016/j.vaccine.2015.09.103
Publication status	Published - 10 Dec 2015
Externally published	Yes

Keywords

Clinical research
Dengue
Immunology
Pathogenesis
Vaccine
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2015.09.103

57794691-oaFinal published version, 1.07 MBLicence: CC BY

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AU - Vinh Chau, Nguyen Van

AU - Hoai Tam, D. T.

AU - Young, Paul

AU - Mackenzie, Jason

AU - Wills, Bridget

PY - 2015/12/10

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AB - This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification.

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KW - Dengue

KW - Immunology

KW - Pathogenesis

KW - Vaccine

KW - Virology

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JO - Vaccine

JF - Vaccine

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ER -

Recent advances in dengue pathogenesis and clinical management

Abstract

Keywords

UN SDGs

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