Reassortment of pandemic H1N1/2009 influenza A virus in swine

D. Vijaykrishna, L. L. M. Poon, H. C. Zhu, S. K. Ma, O. T. W. Li, C. L. Cheung, G. J. D. Smith, J. S. M. Peiris, Y. Guan

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Abstract

The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.
Original languageEnglish
Pages (from-to)1529
Number of pages1
JournalScience
Volume328
DOIs
Publication statusPublished - 18 Jun 2010
Externally publishedYes

Cite this

Vijaykrishna, D., Poon, L. L. M., Zhu, H. C., Ma, S. K., Li, O. T. W., Cheung, C. L., Smith, G. J. D., Peiris, J. S. M., & Guan, Y. (2010). Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science, 328, 1529. https://doi.org/10.1126/science.1189132