Reassortment of pandemic H1N1/2009 influenza A virus in swine

D. Vijaykrishna; L. L. M. Poon; H. C. Zhu; S. K. Ma; O. T. W.  Li; C. L. Cheung; G. J. D.  Smith; J. S. M. Peiris; Y. Guan

doi:10.1126/science.1189132

Reassortment of pandemic H1N1/2009 influenza A virus in swine

D. Vijaykrishna, L. L. M. Poon, H. C. Zhu, S. K. Ma, O. T. W. Li, C. L. Cheung, G. J. D. Smith, J. S. M. Peiris, Y. Guan

Research output: Contribution to journal › Short Survey › Research › peer-review

321 Citations (Scopus)

Abstract

The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.

Original language	English
Pages (from-to)	1529
Number of pages	1
Journal	Science
Volume	328
DOIs	https://doi.org/10.1126/science.1189132
Publication status	Published - 18 Jun 2010
Externally published	Yes

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title = "Reassortment of pandemic H1N1/2009 influenza A virus in swine",

abstract = "The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.",

author = "D. Vijaykrishna and Poon, {L. L. M.} and Zhu, {H. C.} and Ma, {S. K.} and Li, {O. T. W.} and Cheung, {C. L.} and Smith, {G. J. D.} and Peiris, {J. S. M.} and Y. Guan",

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AU - Vijaykrishna, D.

AU - Poon, L. L. M.

AU - Zhu, H. C.

AU - Ma, S. K.

AU - Li, O. T. W.

AU - Cheung, C. L.

AU - Smith, G. J. D.

AU - Peiris, J. S. M.

AU - Guan, Y.

PY - 2010/6/18

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N2 - The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.

AB - The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.

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SN - 0036-8075

VL - 328

SP - 1529

JO - Science

JF - Science

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Reassortment of pandemic H1N1/2009 influenza A virus in swine

Abstract

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