Re-evaluating the role of activin-betaC in cancer biology

Francesco E Marino, Gail P Risbridger, Elspeth J Gold

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Transforming growth factor-beta (TGF-beta) superfamily signaling pathway and its ligands are essential regulators of cellular processes such as proliferation, differentiation, migration, and survival. Alteration of this pathway results in uncontrolled proliferation and cancer progression. This review focuses on a specific member of the TGF-beta superfamily: activin-betaC. After its initial discovery, activin-betaC has been considered non-biologically relevant. Therefore, for years several experimental designs have ignored the potential contribution of this molecule to the final biological outcome. Here we focus on recent advances in the activin field, with a particular emphasis on activin-betaC, its antagonistic mechanism, and the physiological relevance of activin-betaC actions in reproductive and cancer biology. Covering a novel and previously unexplored function of activin-betaC on cancer associated weight loss and muscle metabolism, this review suggests an imminent need to re-evaluate the function of activin-betaC in biological systems and advances the understanding of how activin-betaC antagonizes the activin signaling pathway. Thus, challenging activin biologists to consider the impact of activin-betaC when interpreting their work.
Original languageEnglish
Pages (from-to)463 - 470
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume26
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

Marino, Francesco E ; Risbridger, Gail P ; Gold, Elspeth J. / Re-evaluating the role of activin-betaC in cancer biology. In: Cytokine and Growth Factor Reviews. 2015 ; Vol. 26, No. 4. pp. 463 - 470.
@article{67a0dcd6c1fb492095aa2ecae2f094ac,
title = "Re-evaluating the role of activin-betaC in cancer biology",
abstract = "Transforming growth factor-beta (TGF-beta) superfamily signaling pathway and its ligands are essential regulators of cellular processes such as proliferation, differentiation, migration, and survival. Alteration of this pathway results in uncontrolled proliferation and cancer progression. This review focuses on a specific member of the TGF-beta superfamily: activin-betaC. After its initial discovery, activin-betaC has been considered non-biologically relevant. Therefore, for years several experimental designs have ignored the potential contribution of this molecule to the final biological outcome. Here we focus on recent advances in the activin field, with a particular emphasis on activin-betaC, its antagonistic mechanism, and the physiological relevance of activin-betaC actions in reproductive and cancer biology. Covering a novel and previously unexplored function of activin-betaC on cancer associated weight loss and muscle metabolism, this review suggests an imminent need to re-evaluate the function of activin-betaC in biological systems and advances the understanding of how activin-betaC antagonizes the activin signaling pathway. Thus, challenging activin biologists to consider the impact of activin-betaC when interpreting their work.",
author = "Marino, {Francesco E} and Risbridger, {Gail P} and Gold, {Elspeth J}",
year = "2015",
doi = "10.1016/j.cytogfr.2015.05.003",
language = "English",
volume = "26",
pages = "463 -- 470",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Pergamon",
number = "4",

}

Re-evaluating the role of activin-betaC in cancer biology. / Marino, Francesco E; Risbridger, Gail P; Gold, Elspeth J.

In: Cytokine and Growth Factor Reviews, Vol. 26, No. 4, 2015, p. 463 - 470.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Re-evaluating the role of activin-betaC in cancer biology

AU - Marino, Francesco E

AU - Risbridger, Gail P

AU - Gold, Elspeth J

PY - 2015

Y1 - 2015

N2 - Transforming growth factor-beta (TGF-beta) superfamily signaling pathway and its ligands are essential regulators of cellular processes such as proliferation, differentiation, migration, and survival. Alteration of this pathway results in uncontrolled proliferation and cancer progression. This review focuses on a specific member of the TGF-beta superfamily: activin-betaC. After its initial discovery, activin-betaC has been considered non-biologically relevant. Therefore, for years several experimental designs have ignored the potential contribution of this molecule to the final biological outcome. Here we focus on recent advances in the activin field, with a particular emphasis on activin-betaC, its antagonistic mechanism, and the physiological relevance of activin-betaC actions in reproductive and cancer biology. Covering a novel and previously unexplored function of activin-betaC on cancer associated weight loss and muscle metabolism, this review suggests an imminent need to re-evaluate the function of activin-betaC in biological systems and advances the understanding of how activin-betaC antagonizes the activin signaling pathway. Thus, challenging activin biologists to consider the impact of activin-betaC when interpreting their work.

AB - Transforming growth factor-beta (TGF-beta) superfamily signaling pathway and its ligands are essential regulators of cellular processes such as proliferation, differentiation, migration, and survival. Alteration of this pathway results in uncontrolled proliferation and cancer progression. This review focuses on a specific member of the TGF-beta superfamily: activin-betaC. After its initial discovery, activin-betaC has been considered non-biologically relevant. Therefore, for years several experimental designs have ignored the potential contribution of this molecule to the final biological outcome. Here we focus on recent advances in the activin field, with a particular emphasis on activin-betaC, its antagonistic mechanism, and the physiological relevance of activin-betaC actions in reproductive and cancer biology. Covering a novel and previously unexplored function of activin-betaC on cancer associated weight loss and muscle metabolism, this review suggests an imminent need to re-evaluate the function of activin-betaC in biological systems and advances the understanding of how activin-betaC antagonizes the activin signaling pathway. Thus, challenging activin biologists to consider the impact of activin-betaC when interpreting their work.

UR - http://www.sciencedirect.com/science/article/pii/S1359610115000465

U2 - 10.1016/j.cytogfr.2015.05.003

DO - 10.1016/j.cytogfr.2015.05.003

M3 - Article

VL - 26

SP - 463

EP - 470

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

IS - 4

ER -