Re-evaluating the biological significance of seminal vesicle invasion (SVI) in locally advanced prostate cancer

Nikhil Sapre, John S Pedersen, Matthew K Hong, Laurence Milner Harewood, Justin Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran

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11 Citations (Scopus)


To examine the impact of seminal vesicle invasion (SVI) in patients with locally advanced (pT3) prostate cancer on clinical outcome. To explore the clinical association of SVI with metastatic disease. To distinguish between the possibilities that either seminal vesicles possess their own biological significance and represent a privileged staging site for systemic tumour cell dissemination, or that their invasion is a surrogate marker for an aggressive large-volume poorly differentiated cancer.
Original languageEnglish
Pages (from-to)58 - 63
Number of pages6
JournalBJU International
Issue numberSupp 4
Publication statusPublished - 2012

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