Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Daniel E. Mitchell, Neil R. Cameron, Matthew I. Gibson

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.
Original languageEnglish
Pages (from-to)12977 - 12980
Number of pages4
JournalChemical Communications
Volume51
Issue number65
DOIs
Publication statusPublished - 2015

Cite this

@article{a9fefb1ba5164829b57ef201a7f5b385,
title = "Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation",
abstract = "Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.",
author = "Mitchell, {Daniel E.} and Cameron, {Neil R.} and Gibson, {Matthew I.}",
year = "2015",
doi = "10.1039/c5cc04647e",
language = "English",
volume = "51",
pages = "12977 -- 12980",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "The Royal Society of Chemistry",
number = "65",

}

Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation. / Mitchell, Daniel E.; Cameron, Neil R.; Gibson, Matthew I.

In: Chemical Communications, Vol. 51, No. 65, 2015, p. 12977 - 12980.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

AU - Mitchell, Daniel E.

AU - Cameron, Neil R.

AU - Gibson, Matthew I.

PY - 2015

Y1 - 2015

N2 - Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

AB - Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

UR - http://www.scopus.com/inward/record.url?scp=84938340630&partnerID=8YFLogxK

U2 - 10.1039/c5cc04647e

DO - 10.1039/c5cc04647e

M3 - Article

VL - 51

SP - 12977

EP - 12980

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 65

ER -