Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Daniel E. Mitchell, Neil R. Cameron, Matthew I. Gibson

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.
Original languageEnglish
Pages (from-to)12977 - 12980
Number of pages4
JournalChemical Communications
Volume51
Issue number65
DOIs
Publication statusPublished - 2015

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