Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Daniel E. Mitchell; Neil R. Cameron; Matthew I. Gibson

doi:10.1039/c5cc04647e

Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Daniel E. Mitchell, Neil R. Cameron, Matthew I. Gibson

Materials Science & Engineering

Research output: Contribution to journal › Article › Research › peer-review

72 Citations (Scopus)

Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

Original language	English
Pages (from-to)	12977 - 12980
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	65
DOIs	https://doi.org/10.1039/c5cc04647e
Publication status	Published - 2015

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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Abstract

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