Rat coronary microangiography system for preclinical imaging using synchrotron radiation

Keiji Umetani; James T. Pearson; Daryl O. Schwenke; Mikiyasu Shirai

doi:10.1117/12.2006570

Rat coronary microangiography system for preclinical imaging using synchrotron radiation

Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai

Physiology

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research

1 Citation (Scopus)

Abstract

A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350-400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.

Original language	English
Title of host publication	Medical Imaging 2013: Physics of Medical Imaging
Volume	8668
DOIs	https://doi.org/10.1117/12.2006570
Publication status	Published - 2013
Event	Medical Imaging 2013: Physics of Medical Imaging - Lake Buena Vista, FL, United States of America Duration: 11 Feb 2013 → 14 Feb 2013

Conference

Conference	Medical Imaging 2013: Physics of Medical Imaging
Country	United States of America
City	Lake Buena Vista, FL
Period	11/02/13 → 14/02/13

Keywords

Coronary artery
Endothelium
Microangiography
Preclinical imaging
Synchrotron radiation
Vasodilation

Access to Document

10.1117/12.2006570

Link to publication in Scopus

Cite this

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title = "Rat coronary microangiography system for preclinical imaging using synchrotron radiation",

abstract = "A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350-400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.",

keywords = "Coronary artery, Endothelium, Microangiography, Preclinical imaging, Synchrotron radiation, Vasodilation",

author = "Keiji Umetani and Pearson, {James T.} and Schwenke, {Daryl O.} and Mikiyasu Shirai",

year = "2013",

doi = "10.1117/12.2006570",

language = "English",

isbn = "9780819494429",

volume = "8668",

booktitle = "Medical Imaging 2013: Physics of Medical Imaging",

note = "Medical Imaging 2013: Physics of Medical Imaging ; Conference date: 11-02-2013 Through 14-02-2013",

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T1 - Rat coronary microangiography system for preclinical imaging using synchrotron radiation

AU - Umetani, Keiji

AU - Pearson, James T.

AU - Schwenke, Daryl O.

AU - Shirai, Mikiyasu

PY - 2013

Y1 - 2013

N2 - A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350-400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.

AB - A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350-400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.

KW - Coronary artery

KW - Endothelium

KW - Microangiography

KW - Preclinical imaging

KW - Synchrotron radiation

KW - Vasodilation

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BT - Medical Imaging 2013: Physics of Medical Imaging

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