Rat coronary microangiography system for preclinical imaging using synchrotron radiation

Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

1 Citation (Scopus)

Abstract

A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350-400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.

Original languageEnglish
Title of host publicationMedical Imaging 2013: Physics of Medical Imaging
Volume8668
DOIs
Publication statusPublished - 2013
EventConference on Medical Imaging - Physics of Medical Imaging 2013 - Lake Buena Vista, United States of America
Duration: 11 Feb 201314 Feb 2013
https://spie.org/Publications/Proceedings/Volume/8668 (Proceedings)

Conference

ConferenceConference on Medical Imaging - Physics of Medical Imaging 2013
Country/TerritoryUnited States of America
CityLake Buena Vista
Period11/02/1314/02/13
Internet address

Keywords

  • Coronary artery
  • Endothelium
  • Microangiography
  • Preclinical imaging
  • Synchrotron radiation
  • Vasodilation

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