Abstract
A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350-400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.
Original language | English |
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Title of host publication | Medical Imaging 2013: Physics of Medical Imaging |
Volume | 8668 |
DOIs | |
Publication status | Published - 2013 |
Event | Medical Imaging 2013: Physics of Medical Imaging - Lake Buena Vista, FL, United States of America Duration: 11 Feb 2013 → 14 Feb 2013 |
Conference
Conference | Medical Imaging 2013: Physics of Medical Imaging |
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Country | United States of America |
City | Lake Buena Vista, FL |
Period | 11/02/13 → 14/02/13 |
Keywords
- Coronary artery
- Endothelium
- Microangiography
- Preclinical imaging
- Synchrotron radiation
- Vasodilation