Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study

Ziarih Hawi; Tarrant DR Cummins; Janette Tong; Mauricio Arcos-Burgos; Qiongyi Zhao; Natasha Matthews; Daniel P Newman; Beth Johnson; Alasdair Vance; Helen S Heussler; Florence Levy; Simon Easteal; Naomi Wray; Elaine Kenny; Derek Morris; Lindsay Kent; Michael Gill; Mark A Bellgrove

doi:10.1038/mp.2016.117

Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study

Ziarih Hawi, Tarrant DR Cummins, Janette Tong, Mauricio Arcos-Burgos, Qiongyi Zhao, Natasha Matthews, Daniel P Newman, Beth Johnson, Alasdair Vance, Helen S Heussler, Florence Levy, Simon Easteal, Naomi Wray, Elaine Kenny, Derek Morris, Lindsay Kent, Michael Gill, Mark A Bellgrove

Psychology

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (

Original language	English
Pages (from-to)	580-584
Number of pages	5
Journal	Molecular Psychiatry
Volume	22
DOIs	https://doi.org/10.1038/mp.2016.117
Publication status	Published - Apr 2017

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10.1038/mp.2016.117

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Hawi, Z., Cummins, T. DR., Tong, J., Arcos-Burgos, M., Zhao, Q., Matthews, N., Newman, D. P., Johnson, B., Vance, A., Heussler, H. S., Levy, F., Easteal, S., Wray, N., Kenny, E., Morris, D., Kent, L., Gill, M., & Bellgrove, M. A. (2017). Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study. Molecular Psychiatry, 22, 580-584. https://doi.org/10.1038/mp.2016.117

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abstract = "Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (",

author = "Ziarih Hawi and Cummins, {Tarrant DR} and Janette Tong and Mauricio Arcos-Burgos and Qiongyi Zhao and Natasha Matthews and Newman, {Daniel P} and Beth Johnson and Alasdair Vance and Heussler, {Helen S} and Florence Levy and Simon Easteal and Naomi Wray and Elaine Kenny and Derek Morris and Lindsay Kent and Michael Gill and Bellgrove, {Mark A}",

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doi = "10.1038/mp.2016.117",

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Hawi, Z, Cummins, TDR, Tong, J, Arcos-Burgos, M, Zhao, Q, Matthews, N, Newman, DP, Johnson, B, Vance, A, Heussler, HS, Levy, F, Easteal, S, Wray, N, Kenny, E, Morris, D, Kent, L, Gill, M & Bellgrove, MA 2017, 'Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study', Molecular Psychiatry, vol. 22, pp. 580-584. https://doi.org/10.1038/mp.2016.117

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T1 - Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder

T2 - a next-generation sequencing study

AU - Hawi, Ziarih

AU - Cummins, Tarrant DR

AU - Tong, Janette

AU - Arcos-Burgos, Mauricio

AU - Zhao, Qiongyi

AU - Matthews, Natasha

AU - Newman, Daniel P

AU - Johnson, Beth

AU - Vance, Alasdair

AU - Heussler, Helen S

AU - Levy, Florence

AU - Easteal, Simon

AU - Wray, Naomi

AU - Kenny, Elaine

AU - Morris, Derek

AU - Kent, Lindsay

AU - Gill, Michael

AU - Bellgrove, Mark A

PY - 2017/4

Y1 - 2017/4

N2 - Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (

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JO - Molecular Psychiatry

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ER -

Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study

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