Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study

Ziarih Hawi, Tarrant DR Cummins, Janette Tong, Mauricio Arcos-Burgos, Qiongyi Zhao, Natasha Matthews, Daniel P Newman, Beth Johnson, Alasdair Vance, Helen S Heussler, Florence Levy, Simon Easteal, Naomi Wray, Elaine Kenny, Derek Morris, Lindsay Kent, Michael Gill, Mark A Bellgrove

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25 Citations (Scopus)


Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (
Original languageEnglish
Pages (from-to)580-584
Number of pages5
JournalMolecular Psychiatry
Publication statusPublished - Apr 2017

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