Rapid hypotensive response to fasting in spontaneously hypertensive rats

Sharyn M. Fitzgerald; John E. Hall; Michael W. Brands

doi:10.1016/S0895-7061(01)02209-9

Rapid hypotensive response to fasting in spontaneously hypertensive rats

Sharyn M. Fitzgerald, John E. Hall, Michael W. Brands

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

Original language	English
Pages (from-to)	1123-1127
Number of pages	5
Journal	American Journal of Hypertension
Volume	14
Issue number	11 I
DOIs	https://doi.org/10.1016/S0895-7061(01)02209-9
Publication status	Published - 15 Nov 2001
Externally published	Yes

Keywords

Arterial pressure
Fasting
Sodium intake
Spontaneously hypertensive rats
Sympathetic nervous system

Access to Document

10.1016/S0895-7061(01)02209-9

Link to publication in Scopus

Cite this

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title = "Rapid hypotensive response to fasting in spontaneously hypertensive rats",

abstract = "This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.",

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T1 - Rapid hypotensive response to fasting in spontaneously hypertensive rats

AU - Fitzgerald, Sharyn M.

AU - Hall, John E.

AU - Brands, Michael W.

PY - 2001/11/15

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N2 - This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

AB - This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

KW - Arterial pressure

KW - Fasting

KW - Sodium intake

KW - Spontaneously hypertensive rats

KW - Sympathetic nervous system

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