Rapid hypotensive response to fasting in spontaneously hypertensive rats

Sharyn M. Fitzgerald, John E. Hall, Michael W. Brands

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Abstract

This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

Original languageEnglish
Pages (from-to)1123-1127
Number of pages5
JournalAmerican Journal of Hypertension
Volume14
Issue number11 I
DOIs
Publication statusPublished - 15 Nov 2001
Externally publishedYes

Keywords

  • Arterial pressure
  • Fasting
  • Sodium intake
  • Spontaneously hypertensive rats
  • Sympathetic nervous system

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