Rapid hypotensive response to fasting in spontaneously hypertensive rats

Sharyn M. Fitzgerald; John E. Hall; Michael W. Brands

doi:10.1016/S0895-7061(01)02209-9

Rapid hypotensive response to fasting in spontaneously hypertensive rats

Sharyn M. Fitzgerald, John E. Hall, Michael W. Brands

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

Original language	English
Pages (from-to)	1123-1127
Number of pages	5
Journal	American Journal of Hypertension
Volume	14
Issue number	11 I
DOIs	https://doi.org/10.1016/S0895-7061(01)02209-9
Publication status	Published - 15 Nov 2001
Externally published	Yes

Keywords

Arterial pressure
Fasting
Sodium intake
Spontaneously hypertensive rats
Sympathetic nervous system

Access to Document

10.1016/S0895-7061(01)02209-9

Cite this

@article{1a4925d1c8bc49a6a99157f31f11b2ac,

title = "Rapid hypotensive response to fasting in spontaneously hypertensive rats",

abstract = "This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.",

keywords = "Arterial pressure, Fasting, Sodium intake, Spontaneously hypertensive rats, Sympathetic nervous system",

author = "Fitzgerald, {Sharyn M.} and Hall, {John E.} and Brands, {Michael W.}",

year = "2001",

month = nov,

day = "15",

doi = "10.1016/S0895-7061(01)02209-9",

language = "English",

volume = "14",

pages = "1123--1127",

journal = "American Journal of Hypertension",

issn = "0895-7061",

publisher = "Oxford University Press",

number = "11 I",

}

TY - JOUR

T1 - Rapid hypotensive response to fasting in spontaneously hypertensive rats

AU - Fitzgerald, Sharyn M.

AU - Hall, John E.

AU - Brands, Michael W.

PY - 2001/11/15

Y1 - 2001/11/15

N2 - This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

AB - This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.

KW - Arterial pressure

KW - Fasting

KW - Sodium intake

KW - Spontaneously hypertensive rats

KW - Sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=0034761241&partnerID=8YFLogxK

U2 - 10.1016/S0895-7061(01)02209-9

DO - 10.1016/S0895-7061(01)02209-9

M3 - Article

C2 - 11724211

AN - SCOPUS:0034761241

SN - 0895-7061

VL - 14

SP - 1123

EP - 1127

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 11 I

ER -

Rapid hypotensive response to fasting in spontaneously hypertensive rats

Abstract

Keywords

Access to Document

Other files and links

Cite this