Abstract
This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.
Original language | English |
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Pages (from-to) | 1123-1127 |
Number of pages | 5 |
Journal | American Journal of Hypertension |
Volume | 14 |
Issue number | 11 I |
DOIs | |
Publication status | Published - 15 Nov 2001 |
Externally published | Yes |
Keywords
- Arterial pressure
- Fasting
- Sodium intake
- Spontaneously hypertensive rats
- Sympathetic nervous system